DU145 (DU-145) is a human prostate cancer cell line.[1] DU145, PC3, and LNCaP are considered to be the standard prostate cancer cell lines used in therapeutic research.[1]
The DU145 cell line was derived from a central nervous system metastasis, of primary prostate adenocarcinoma origin, removed during a parieto-occipital craniotomy of a 69-year-old, White, male.[2][3] DU145 are not hormone-sensitive and do not express prostate-specific antigen (PSA). DU145 cells have moderate metastatic potential compared to PC3 cells, which have high metastatic potential.[citation needed]
- ^ a b Alimirah, Fatouma; Chen, Jianming; Basrawala, Zane; Xin, Hong; Choubey, Divaker (2006-04-17). "DU-145 and PC-3 human prostate cancer cell lines express androgen receptor: Implications for the androgen receptor functions and regulation". FEBS Letters. 580 (9): 2294–2300. doi:10.1016/j.febslet.2006.03.041. PMID 16580667. S2CID 21777101.
- ^ "DU 145 - HTB-81 | ATCC". www.atcc.org. Retrieved 2023-04-18.
- ^ Stone, Kenneth R.; Mickey, Don D.; Wunderli, Heidi; Mickey, George H.; Paulson, David F. (1978-03-15). "Isolation of a human prostate carcinoma cell line (DU 145)". International Journal of Cancer. 21 (3): 274–281. doi:10.1002/ijc.2910210305. PMID 631930. S2CID 26978561.