Dacarbazine

Dacarbazine
Clinical data
Pronunciation/dəˈkɑːrbəˌziːn/
Trade namesDTIC-Dome, others
Other namesDTIC[1]
AHFS/Drugs.comMonograph
MedlinePlusa682750
Routes of
administration		Intravenous
ATC code
Legal status
Legal status
  • US: WARNING[2]Rx-only
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability100%
MetabolismExtensive
Elimination half-life5 hours
ExcretionKidney (40% as unchanged dacarbazine)
Identifiers
  • 5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.022.179 Edit this at Wikidata
Chemical and physical data
FormulaC6H10N6O
Molar mass182.187 g·mol−1
3D model (JSmol)
  • CN(C)N=Nc1[nH]cnc1C(N)=O
  • InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)/b11-10+ checkY
  • Key:FDKXTQMXEQVLRF-ZHACJKMWSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Dacarbazine, also known as imidazole carboxamide and sold under the brand name DTIC-Dome, is a chemotherapy medication used in the treatment of melanoma and Hodgkin's lymphoma.[3] For Hodgkin's lymphoma it is often used together with vinblastine, bleomycin, and doxorubicin.[3] It is given by injection into a vein.[3]

Common side effects include loss of appetite, vomiting, low white blood cell count, and low platelets.[3] Other serious side effects include liver problems and allergic reactions.[3] It is unclear if use in pregnancy is safe for the baby.[3] Dacarbazine is in the alkylating agent and purine analog families of medication.[3]

Dacarbazine was approved for medical use in the United States in 1975.[3] It is on the World Health Organization's List of Essential Medicines.[4]

  1. ^ Elks J, Ganellin CR, eds. (1990). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 344–. doi:10.1007/978-1-4757-2085-3. ISBN 978-1-4757-2087-7.
  2. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved October 22, 2023.
  3. ^ a b c d e f g h "Dacarbazine". The American Society of Health-System Pharmacists. Archived from the original on September 11, 2017. Retrieved December 8, 2016.
  4. ^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.