Daniel Geschwind

Daniel H. Geschwind
Alma materDartmouth College, Yale School of Medicine
Awards
Scientific career
FieldsHuman genetics, neurogenetics
InstitutionsUniversity of California, Los Angeles
Doctoral advisorSusan Hockfield

Daniel H. Geschwind is an American physician-scientist whose laboratory has made pioneering discoveries in the biology of brain disorders and the genetic and genomic analyses of the nervous system.

His laboratory showed that gene co-expression has a reproducible network structure that can be used to understand neurobiological mechanisms in health, evolution, and disease.[2][3][4] He led the first studies to define the molecular pathology of autism spectrum disorder (ASD) and several other psychiatric disorders,[5][6][7] and has made major contributions to defining the genetic basis of autism.[8][9][10]

Currently, he is the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics, Neurology and Psychiatry at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). He also directs the UCLA Neurogenetics Program and the UCLA Center for Autism Research and Treatment (CART).[11][12] Since March 2016 he has served as the Senior Associate Dean and Associate Vice Chancellor for Precision Health at UCLA.[13]

  1. ^ "Daniel Geschwind". NAM Member Profiles.
  2. ^ Winden, Kellen D.; Oldham, Michael C.; Mirnics, Karoly; Ebert, Philip J.; Swan, Christo H.; Levitt, Pat; Rubenstein, John L.; Horvath, Steve; Geschwind, Daniel H. (2009). "The organization of the transcriptional network in specific neuronal classes". Molecular Systems Biology. 5: 291. doi:10.1038/msb.2009.46. ISSN 1744-4292. PMC 2724976. PMID 19638972.
  3. ^ Oldham, Michael C.; Horvath, Steve; Geschwind, Daniel H. (2006-11-21). "Conservation and evolution of gene coexpression networks in human and chimpanzee brains". Proceedings of the National Academy of Sciences of the United States of America. 103 (47): 17973–17978. Bibcode:2006PNAS..10317973O. doi:10.1073/pnas.0605938103. ISSN 0027-8424. PMC 1693857. PMID 17101986.
  4. ^ Oldham, Michael C.; Konopka, Genevieve; Iwamoto, Kazuya; Langfelder, Peter; Kato, Tadafumi; Horvath, Steve; Geschwind, Daniel H. (November 2008). "Functional organization of the transcriptome in human brain". Nature Neuroscience. 11 (11): 1271–1282. doi:10.1038/nn.2207. ISSN 1546-1726. PMC 2756411. PMID 18849986.
  5. ^ Gandal, Michael J.; Zhang, Pan; Hadjimichael, Evi; Walker, Rebecca L.; Chen, Chao; Liu, Shuang; Won, Hyejung; van Bakel, Harm; Varghese, Merina; Wang, Yongjun; Shieh, Annie W.; Haney, Jillian; Parhami, Sepideh; Belmont, Judson; Kim, Minsoo (2018-12-14). "Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder". Science. 362 (6420): eaat8127. Bibcode:2018Sci...362.8127G. doi:10.1126/science.aat8127. ISSN 1095-9203. PMC 6443102. PMID 30545856.
  6. ^ Parikshak, Neelroop N.; Swarup, Vivek; Belgard, T. Grant; Irimia, Manuel; Ramaswami, Gokul; Gandal, Michael J.; Hartl, Christopher; Leppa, Virpi; Ubieta, Luis de la Torre; Huang, Jerry; Lowe, Jennifer K.; Blencowe, Benjamin J.; Horvath, Steve; Geschwind, Daniel H. (2016-12-15). "Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism". Nature. 540 (7633): 423–427. Bibcode:2016Natur.540..423P. doi:10.1038/nature20612. ISSN 1476-4687. PMC 7102905. PMID 27919067.
  7. ^ Voineagu, Irina; Wang, Xinchen; Johnston, Patrick; Lowe, Jennifer K.; Tian, Yuan; Horvath, Steve; Mill, Jonathan; Cantor, Rita M.; Blencowe, Benjamin J.; Geschwind, Daniel H. (2011-05-25). "Transcriptomic analysis of autistic brain reveals convergent molecular pathology". Nature. 474 (7351): 380–384. doi:10.1038/nature10110. ISSN 1476-4687. PMC 3607626. PMID 21614001.
  8. ^ "Daniel Geschwind: After many detours, on the trail of autism's genetics". The Transmitter: Neuroscience News and Perspectives. 2009-02-17. Retrieved 2024-08-08.
  9. ^ "Dr. Daniel Geschwind Receives 2012 Ruane Prize for Outstanding Achievement in Autism Research". Dr. Daniel Geschwind Receives 2012 Ruane Prize for Outstanding Achievement in Autism Research | Brain & Behavior Research Foundation. 2012-11-07. Retrieved 2024-08-08.
  10. ^ Cite error: The named reference :0 was invoked but never defined (see the help page).
  11. ^ "Daniel H. Geschwind". UCLA Website. Retrieved 12 February 2018.
  12. ^ Cite error: The named reference allen was invoked but never defined (see the help page).
  13. ^ "Daniel H. Geschwind". UCLA Newsroom. Retrieved 17 May 2016.