| Darejan of Kakheti | |
|---|---|
 Darejan, Queen of Imereti. A sketch by the contemporary Italian missionary Cristoforo Castelli. | |
| Queen consort of Imereti | |
| Tenure | 1639–1660 1661–1663 1668 |
| Born | c. 1615 |
| Died | 1668 |
| Burial | |
| Spouse | Zurab, Duke of Aragvi Alexander III of Imereti Vakhtang of Imereti |
| Issue | Leonti |
| Dynasty | Bagrationi |
| Father | Teimuraz I of Kakheti |
| Mother | Khorashan of Kartli |
| Religion | Georgian Orthodox Church |
| Khelrtva | .svg) |
Darejan (Georgian: დარეჯანი) or Nestan-Darejan (ნესტან-დარეჯანი) (c. 1615 – 1668) was a daughter of King Teimuraz I, a ruler of Kakheti in eastern Georgia, with a notable role in the contemporary politics of Georgia. Her three marriages represented a component of her family's and her own political machinations. Her first husband, Zurab, Duke of Aragvi, was put to death at the behest of Darejan's father in 1630. Her second and third marriages, to Alexander III and Vakhtang I, respectively in 1630 and 1661, made her a queen consort of Imereti, in western Georgia, where Darejan became embroiled in a series coups and counter-coups. She was eventually murdered by members of the rival party in Kutaisi.