Dark proteome

The dark proteome is defined as proteins with no defined three-dimensional structure. It can not be detected or analyzed with the use of homologous modeling or analytical quantification for the molecular conformation is unknown.[1] Dark proteins are mostly composed of unknown unknowns.[2]

  1. ^ Perdigão, Nelson; Rosa, Agostinho (2019). "Dark Proteome Database: Studies on Dark Proteins". High-Throughput. 8 (2): 8. doi:10.3390/ht8020008. PMC 6630768. PMID 30934744.
  2. ^ Perdigão, Nelson; et al. (2015). "Unexpected features of the dark proteome". PNAS. 112 (52): 15898–15903. Bibcode:2015PNAS..11215898P. doi:10.1073/pnas.1508380112. PMC 4702990. PMID 26578815.