Dasabuvir

Dasabuvir
Clinical data
Trade namesExviera, Viekira Pak, Viekira XR
Other namesABT-333
AHFS/Drugs.comViekira Pak Monograph
Dasabuvir UK Drug Information
MedlinePlusa616040
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • US: ℞-only co-packaged with ombitasvir/paritaprevir/ritonavir (Viekira Pak)[1]
  • EU: Rx-only[2]
Identifiers
  • N-{6-[5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-methoxy-3-(2-methyl-2-propanyl)phenyl]-2-naphthyl}methanesulfonamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.232.246 Edit this at Wikidata
Chemical and physical data
FormulaC26H27N3O5S
Molar mass493.58 g·mol−1
3D model (JSmol)
  • CC(C)(C)c1cc(cc(c1OC)c2ccc3cc(ccc3c2)NS(=O)(=O)C)n4ccc(=O)[nH]c4=O
  • InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)
  • Key:NBRBXGKOEOGLOI-UHFFFAOYSA-N

Dasabuvir, sold under the brand name Exviera, is an antiviral medication for the treatment of hepatitis C.[3] It is often used together with the combination medication ombitasvir/paritaprevir/ritonavir specifically for hepatitis C virus (HCV) type 1.[3] Ribavirin may also additionally be used.[1][2] These combinations result in a cure in more than 90% of people.[4] It is taken by mouth.[3]

Common side effects include trouble sleeping, nausea, itchiness, and feeling tired.[4] It is not recommended in those with liver failure but appears okay in people with kidney disease.[3] While there is no evidence of harm if used during pregnancy, it has not been well studied.[3] It should not be used with birth control pills that contain ethinylestradiol.[4] Dasabuvir is in the HCV NS5B polymerase inhibitor class of medication.[3]

Dasabuvir was approved for medical use in 2014.[5] It is on the World Health Organization's List of Essential Medicines.[6] In the United States, it is approved by the Food and Drug Administration (FDA) only for use in combination with ombitasvir/paritaprevir/ritonavir.[3] As of 2015, the ability to get these medications in many areas of the world is poor.[7]

  1. ^ a b Cite error: The named reference Viekira Pak FDA label was invoked but never defined (see the help page).
  2. ^ a b Cite error: The named reference Exviera EPAR was invoked but never defined (see the help page).
  3. ^ a b c d e f g "Viekira Pak". The American Society of Health-System Pharmacists. Archived from the original on 20 December 2016. Retrieved 8 December 2016.
  4. ^ a b c "European Medicines Agency - Find medicine - Exviera". www.ema.europa.eu. 24 May 2016. Archived from the original on 10 November 2016. Retrieved 2016-11-09.
  5. ^ Časar, Zdenko (2016). Synthesis of Heterocycles in Contemporary Medicinal Chemistry. Springer. p. 92. ISBN 9783319399171. Archived from the original on 2016-12-20.
  6. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  7. ^ World Health Organization (2015). The selection and use of essential medicines. Twentieth report of the WHO Expert Committee 2015 (including 19th WHO Model List of Essential Medicines and 5th WHO Model List of Essential Medicines for Children). World Health Organization. p. 73. hdl:10665/189763. ISBN 9789241209946. ISSN 0512-3054. WHO technical report series;994.