Death receptor 3

TNFRSF25
Identifiers
AliasesTNFRSF25, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR, tumor necrosis factor receptor superfamily member 25, TNF receptor superfamily member 25, GEF720, PLEKHG5
External IDsOMIM: 603366; MGI: 1934667; HomoloGene: 13202; GeneCards: TNFRSF25; OMA:TNFRSF25 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001291010
NM_033042

RefSeq (protein)

n/a

Location (UCSC)Chr 1: 6.46 – 6.47 MbChr 4: 152.2 – 152.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation.[5][6][7] Its only known TNFSF ligand is TNF-like protein 1A (TL1A).[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000215788Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024793Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, Wilson A, French LE, Browning JL, MacDonald HR, Tschopp J (Jan 1997). "TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95)". Immunity. 6 (1): 79–88. doi:10.1016/S1074-7613(00)80244-7. PMID 9052839.
  6. ^ Kitson J, Raven T, Jiang YP, Goeddel DV, Giles KM, Pun KT, Grinham CJ, Brown R, Farrow SN (Nov 1996). "A death-domain-containing receptor that mediates apoptosis". Nature. 384 (6607): 372–5. Bibcode:1996Natur.384..372K. doi:10.1038/384372a0. PMID 8934525. S2CID 4283742.
  7. ^ "Entrez Gene: TNFRSF25 tumor necrosis factor receptor superfamily, member 25".
  8. ^ Wang EC (Sep 2012). "On death receptor 3 and its ligands…". Immunology. 137 (1): 114–6. doi:10.1111/j.1365-2567.2012.03606.x. PMC 3449252. PMID 22612445.