Death train may refer to:
- Death trains, an alternative name for Holocaust trains, used to transport Jews to Nazi concentration and extermination camps
- Death Train, a novel by Alastair MacNeill, based on the UNACO screenplay by Alistair MacLean
- Death Train, first of The Sergeant series of novels by Len Levinson writing as Gordon Davis
- "Death Train", a song from the album Sinking the Eight Ball by Ruby Joe
- "The Death Train", El tren de la muerte, or La Bestia, a dangerous network of Mexican freight trains that are utilized by U.S.- bound migrants to more quickly traverse the length of Mexico