Dedisimedi (Georgian: დედისიმედი; died c. 1595) was a Georgian noblewoman of the House of Mukhrani, a collateral branch of the royal Bagrationi dynasty. She was princess consort of Samtskhe as wife of Kaikhosro II Jaqeli (r. 1545–1573) and regent for her son Qvarqvare IV Jaqeli (r. 1573–1581). She played a leading role in a civil war that plagued Samtskhe from 1576 to 1578. After the Ottoman takeover of her principality, Dedisimedi retired to Kartli, leaving the government to her son, Manuchar II Jaqeli, who continued to rule as an Ottoman pasha.