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| ECHA InfoCard | 100.042.305 |
| Chemical and physical data | |
| Formula | C14H21NO15S |
| Molar mass | 475.37 g·mol−1 |
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Dermatan sulfate is a glycosaminoglycan (formerly called a mucopolysaccharide) found mostly in skin, but also in blood vessels, heart valves, tendons, and lungs.
It is also referred to as chondroitin sulfate B,[1] although it is no longer classified as a form of chondroitin sulfate by most sources. The formula is C14H21NO15S. This carbohydrate is composed of linear polymers of disaccharide units that contain, N-acetyl galactosamine (GalNAc) and iduronic acid (IdoA). These repeating units are sulfated at a variety of positions.[2] Dermatan sulfate is a component of the compound sulodexide.[3]
- ^ Trowbridge JM, Gallo RL (September 2002). "Dermatan sulfate: new functions from an old glycosaminoglycan". Glycobiology. 12 (9): 117R–125R. doi:10.1093/glycob/cwf066. PMID 12213784.
- ^ "Dermatan sulfate".
- ^ Lasierra-Cirujeda J, Coronel P, Aza M, Gimeno M (2010). "Use of sulodexide in patients with peripheral vascular disease". Journal of Blood Medicine. 1: 105–115. doi:10.2147/JBM.S10558. PMC 3262318. PMID 22282689.
Sulodexide is a highly purified glycosaminoglycan (GAG) obtained from porcine digestive mucosa and is composed of a mixture of 80% heparan sulfate (an electrophoretically fast moving fraction with a low molecular weight of 7000 Da and affinity for antithrombin III) and 20% dermatan sulfate with a high molecular weight (25,000 Da) and affinity for the heparin II cofactor.