Desert hedgehog (protein)

DHH
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDHH, GDXYM, HHG-3, SRXY7, C78960, desert hedgehog, desert hedgehog signaling molecule, GDMN
External IDsOMIM: 605423; MGI: 94891; HomoloGene: 22431; GeneCards: DHH; OMA:DHH - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021044

NM_007857

RefSeq (protein)

NP_066382

NP_031883

Location (UCSC)Chr 12: 49.09 – 49.09 MbChr 15: 98.79 – 98.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
desert hedgehog
Identifiers
SymbolDHH
Alt. symbolsHHG-3, MGC35145
NCBI gene50846
HGNC2865
OMIM605423
RefSeqNM_021044
UniProtO43323
Other data
LocusChr. 12 q13.1
Search for
StructuresSwiss-model
DomainsInterPro

Desert hedgehog, also Desert hedgehog homolog or Dhh, is a protein encoded by the DHH gene, and is a member of the hedgehog signaling pathway. The human homolog (DHH) is on chromosome band 12q13.1.[5][6] The protein encoded by this gene is involved in cell signaling. The several mammalian variants of the Drosophila hedgehog gene (which was the first named) have been named after the various species of hedgehog; the desert hedgehog is honored by this one. The gene is not specific to desert hedgehogs.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139549Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023000Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kamisago M, Kimura M, Furutani Y, Furutani M, Takao A, Momma K, Matsuoka R (1999). "Assignment of human desert hedgehog gene (DHH) to chromosome band 12q13.1 by in situ hybridization". Cytogenet. Cell Genet. 87 (1–2): 117–8. doi:10.1159/000015376. PMID 10640830. S2CID 2152329.
  6. ^ Tate G, Satoh H, Endo Y, Mitsuya T (2000). "Assignment of desert hedgehog (DHH) to human chromosome bands 12q12→q13.1 by in situ hybridization". Cytogenet. Cell Genet. 88 (1–2): 93–4. doi:10.1159/000015495. PMID 10773676. S2CID 36364525.