Desmocollins are a subfamily of desmosomal cadherins, the transmembrane constituents of desmosomes.[3][4] They are co-expressed with desmogleins to link adjacent cells by extracellular adhesion. There are seven desmosomal cadherins in humans, three desmocollins and four desmogleins.[4] Desmosomal cadherins allow desmosomes to contribute to the integrity of tissue structure in multicellular living organisms.[5]
- ^ Harrison, Oliver J.; Brasch, Julia; Lasso, Gorka; Katsamba, Phinikoula S.; Ahlsen, Goran; Honig, Barry; Shapiro, Lawrence (2016-06-28). "Structural basis of adhesive binding by desmocollins and desmogleins". Proceedings of the National Academy of Sciences. 113 (26): 7160–7165. Bibcode:2016PNAS..113.7160H. doi:10.1073/pnas.1606272113. ISSN 0027-8424. PMC 4932976. PMID 27298358.
- ^ Bank, RCSB Protein Data. "RCSB PDB - 5IRY: Crystal structure of human Desmocollin-1 ectodomain". www.rcsb.org. Retrieved 2020-04-25.
- ^ Desmocollins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ a b Garrod D, Chidgey M (March 2008). "Desmosome structure, composition and function". Biochimica et Biophysica Acta (BBA) - Biomembranes. Apical Junctional Complexes Part I. 1778 (3): 572–87. doi:10.1016/j.bbamem.2007.07.014. PMID 17854763.
- ^ Sun C, Wang L, Yang XX, Jiang YH, Guo XL (June 2019). "The aberrant expression or disruption of desmocollin2 in human diseases". International Journal of Biological Macromolecules. 131: 378–386. doi:10.1016/j.ijbiomac.2019.03.041. PMID 30851326. S2CID 73495230.