Deso, DeSo, or DESO may refer to:
- DeSo, a social media-oriented blockchain created in 2021
- $DESO, the native cryptocurrency of the DeSo blockchain
- Designated driver, in Australian slang
- UK Defence and Security Exports, a British arms export organization formerly known as "Defence Export Services Organisation"
- Deso Kalvin (fl. 2021–2022), a cricket player from Seychelles
- RKVV DESO, a Dutch football club
- An acronym for "direct effect of social origins", in Social mobility
- Departmental Entry Subordinate Officers, a kind of assistant commandant in India
- Deso (fl. 1920), a player in the Serbian football club FK Vojvodina; see List of FK Vojvodina players
- Any drug whose name begins with "deso"; see List of drugs: De#deso-desy