Clinical data | |
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Trade names | Cerazette, Lovima, Hana, others |
Other names | DSG; ORG-2969; 3-Deketo-11-methylene-17α-ethynyl-18-methyl-19-nortestosterone; 11-Methylene-17α-ethynyl-18-methylestr-4-en-17β-ol |
AHFS/Drugs.com | Multum Consumer Information |
MedlinePlus | a601050 |
License data |
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Routes of administration | By mouth[1] |
Drug class | Progestogen |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 76% (range 40–100%)[11][12] |
Protein binding | Desogestrel: 99%:[13] • Albumin: 99% Etonogestrel: 95–98%:[1][14] • Albumin: 65–66% • SHBG : 30–32% • Free: 2–5% |
Metabolism | Liver, intestines (5α- and 5β-reductase, cytochrome P450 enzymes, others)[14] |
Metabolites | • Etonogestrel[14][1][11] • Others[13][14][11] |
Elimination half-life | Desogestrel: 1.5 hours[13] Etonogestrel: 21–38 hrs[13][15] |
Excretion | Urine: 50%[13] Feces: 35%[13] |
Identifiers | |
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CAS Number | |
PubChem CID | |
IUPHAR/BPS | |
DrugBank | |
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KEGG | |
ChEBI | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.053.555 |
Chemical and physical data | |
Formula | C22H30O |
Molar mass | 310.481 g·mol−1 |
3D model (JSmol) | |
Melting point | 109 to 110 °C (228 to 230 °F) |
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Desogestrel is a progestin medication which is used in birth control pills.[1][14] It is also used in the treatment of menopausal symptoms in women.[1] The medication is available and used alone or in combination with an estrogen.[1][14] It is taken by mouth.[1]
Side effects of desogestrel include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and others.[1] Desogestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone.[1][14] It has very weak androgenic and glucocorticoid activity and no other important hormonal activity.[14] The medication is a prodrug of etonogestrel (3-ketodesogestrel) in the body.[1][14]
Desogestrel was discovered in 1972 and was introduced for medical use in Europe in 1981.[16][13][17] It became available in the United States in 1992.[18][19][20] Desogestrel is sometimes referred to as a "third-generation" progestin.[21] Likenorethisterone and Norgestrel, Desogestrel is widely available as a progestogen-only "mini pill" for birth control.[22][23][24] Desogestrel is marketed widely throughout the world.[25] It is available as a generic medication.[26] In 2020, the version with ethinylestradiol was the 120th most commonly prescribed medication in the United States, with more than 5 million prescriptions.[27][28]
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