A destroying angel is any of several closely related deadly species of Amanita mushrooms.
Destroying angel may also refer to:
- Destroying angel (Bible), in various passages
- "Destroying Angel" (Midsomer Murders episode)
- Destroying Angel (film), a 1923 American silent film directed by W. S. Van Dyke
- Destroying Angel, a 1987 Anglo-Yugoslavian film directed by Arne Mattsson, later retitled Sleep Well My Love
- Destroying Angel, a science fiction novel by Richard Paul Russo
- "Destroying Angel", a song by Sneaker Pimps from Splinter
- Destroying Angels, members of the Mormon Danites
- "The Destroying Angel", a song by Anaal Nathrakh from Eschaton
- "Destroying Angels, a song by Garbage with John Doe and Exene Cervenka of X
- "The Destroying Angel," a 1976 gay pornographic film directed by Peter De Rome and based loosely on Edgar Allan Poe's "William Wilson."
- “Destroying Angel” is the second episode from the 1972 TV series Van Der Valk.