Enzyme that breaks down diacylglycerol in many organisms.
diacylglycerol lipase α
DAGLα structure, folded with AlphaFold.[1][2][3]
Transmembrane domain in marine blue. Catalytic domain in yellow. C-terminal tail in gray. See Structure for details. Click image for higher resolution.
DAGLβ structure, folded with AlphaFold.[1][2][3] Transmembrane domain in marine blue. Catalytic domain in yellow. Note missing C-terminal tail. See Structure for details. Click image for higher resolution.
DAGL has been studied in multiple domains of life, including bacteria, fungi, plants, insects, and mammals.[4] By searching with BLAST for the previously sequenced microorganism DAGL,[5] Bisogno et al discovered two distinct mammalian isoforms, designated DAGLα (DAGLA) and DAGLβ (DAGLB).[1] Most animal DAGL enzymes cluster into the DAGLα and DAGLβ isoforms.[4]