Nonsteroidal anti-inflammatory drug
"Diclo" redirects here. For the organic solvent sometimes called Di-clo, see
Dichloromethane .
Diclofenac Structure of diclofenac with ball and stick model
Pronunciation [ 1] or [ 2] Trade names Voltaren, others [ 1] AHFS /Drugs.com Monograph MedlinePlus a689002 License data
Pregnancy category Routes of administration Orally , rectal , intramuscular , intravenous , topical , ophthalmic Drug class Nonsteroidal anti-inflammatory agents ATC code Legal status
Protein binding More than 99% Metabolism Liver, oxidative, primarily by CYP2C9 , also by CYP2C8 , CYP3A4 , as well as conjugative by glucuronidation (UGT2B7 ) and sulfation ;[ 11] no active metabolites exist Onset of action Within 4 hours (gel), 30 min (non-gel)[ 9] Elimination half-life 1.2–2 h (35% of the drug enters enterohepatic recirculation) Excretion 35% bile , 65% urine [ 10]
[2-(2,6-Dichloroanilino)phenyl]acetic acid
CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL PDB ligand CompTox Dashboard (EPA ) ECHA InfoCard 100.035.755 Formula C 14 H 11 Cl 2 N O 2 Molar mass 296.15 g·mol−1 3D model (JSmol )
O=C(O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
Y Key:DCOPUUMXTXDBNB-UHFFFAOYSA-N
Y
N Y (what is this?) (verify)
Diclofenac , sold under the brand name Voltaren among others, is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammatory diseases such as gout .[ 6] [ 9] It can be taken orally (swallowed by mouth), inserted rectally as a suppository , injected intramuscularly , injected intravenously , applied to the skin topically , or through eye drops .[ 9] [ 12] [ 13] Improvements in pain last up to eight hours.[ 9] It is also available as the fixed-dose combination diclofenac/misoprostol (Arthrotec) to help protect the stomach.[ 14] [ 15]
Common side effects include abdominal pain , gastrointestinal bleeding , nausea, dizziness, headache, and swelling.[ 9] Serious side effects may include heart disease , stroke , kidney problems , and stomach ulceration .[ 15] [ 9] Use is not recommended in the third trimester of pregnancy .[ 9] It is likely safe during breastfeeding .[ 15] Diclofenac is believed to work by decreasing the production of prostaglandins , like other drugs in this class.[ 16]
In 2022, it was the 51st most commonly prescribed medication in the United States, with more than 12 million prescriptions.[ 17] [ 18] It is available as its acid or in two salts, as either diclofenac sodium or potassium.[ 15]
^ a b Cite error: The named reference tn
was invoked but never defined (see the help page ).
^ O'Toole MT, ed. (2017). Mosby's Dictionary of Medicine, Nursing & Health Professions (10th ed.). Elsevier. p. 536. ISBN 978-0-323-22205-1 .
^ "Diclofenac Use During Pregnancy" . Drugs.com . 16 January 2000. Retrieved 18 February 2024 .
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)" . nctr-crs.fda.gov . FDA . Retrieved 22 October 2023 .
^ "Product monograph brand safety updates" . Health Canada . 6 June 2024. Retrieved 8 June 2024 .
^ a b "Voltaren Arthritis Pain- diclofenac sodium gel; Voltaren Arthritis Pain- diclofenac sodium kit" . DailyMed . 13 March 2024. Retrieved 13 October 2024 .
^ "Cambia- diclofenac potassium powder, for solution" . DailyMed . 25 April 2024. Retrieved 13 October 2024 .
^ "FDA Approves Three Drugs for Nonprescription Use Through Rx-to-OTC Switch Process" . U.S. Food and Drug Administration (FDA) . 14 February 2020. Retrieved 18 February 2024 . This article incorporates text from this source, which is in the public domain .
^ a b c d e f g "Diclofenac epolamine Monograph for Professionals" . Drugs.com . Retrieved 18 February 2024 .
^ Williams BS, Buvanendran A (1 January 2011). "Nonopioid analgesics: NSAIDs, COX-2 inhibitors, and acetaminophen" . In Benzon HT, Raja SN, Liu SS, Fishman SM (eds.). Essentials of Pain Medicine (3 ed.). W.B. Saunders. pp. 130–139. doi :10.1016/b978-1-4377-2242-0.00026-2 . ISBN 978-1-4377-2242-0 . Archived from the original on 10 January 2023. Retrieved 10 January 2023 .
^ Sayyad M (23 August 2018). "Diclofenac Oral Uses, Dosage, Side Effects And Composition" . Medicine Reviews Agency. Archived from the original on 24 August 2018. Retrieved 18 February 2024 .
^ Chung CH (2017). "The use of Injectable Nonsteroidal Anti-Inflammatory Drugs in Local Accident & Emergency Practice". Hong Kong Journal of Emergency Medicine . 9 (2): 65–71. doi :10.1177/102490790200900201 . S2CID 74032271 .
^ "Diclofenac Ophthalmic" . medlineplus.gov . 15 July 2016. Retrieved 8 October 2024 .
^ "Arthrotec- diclofenac sodium and misoprostol tablet, film coated" . DailyMed . 16 August 2023. Retrieved 13 October 2024 .
^ a b c d British national formulary : BNF 74 (74 ed.). British Medical Association. 2017. pp. 1033–1035. ISBN 978-0-85711-298-9 .
^ Mosby's Drug Reference for Health Professions . Elsevier Health Sciences. 2017. p. 398. ISBN 978-0-323-56682-7 .
^ "The Top 300 of 2022" . ClinCalc . Archived from the original on 30 August 2024. Retrieved 30 August 2024 .
^ "Diclofenac Drug Usage Statistics, United States, 2013 - 2022" . ClinCalc . Retrieved 30 August 2024 .