Diclofenac/misoprostol

Diclofenac/misoprostol
Combination of
DiclofenacNSAID
MisoprostolProstaglandin analog
Clinical data
Trade namesArthrotec
MedlinePlusa699002
License data
Pregnancy
category
  • Contraindicated
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
KEGG
  (verify)

Diclofenac/misoprostol, sold under the brand name Arthrotec, is a fixed-dose combination medication that contains:

In the United Kingdom it is marketed by Pharmacia and it is indicated for prophylaxis against NSAID-induced gastroduodenal ulceration in people requiring diclofenac for rheumatoid arthritis or osteoarthritis.[2]

The American College of Rheumatology and a Canadian consensus report both recommend GI-protective agents such as misoprostol be combined with long term NSAID therapy and a review concluded that diclofenac/misoprostol is a cost effective treatment in patients requiring long term NSAID therapy who are at increased risk of developing gastropathy.[4]

  1. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  2. ^ a b "Arthrotec 50 modified-release Tablets - Summary of Product Characteristics (SmPC)". (emc). 17 March 2021. Retrieved 3 August 2021.
  3. ^ "Arthrotec- diclofenac sodium and misoprostol tablet, film coated". DailyMed. Retrieved 3 August 2021.
  4. ^ Plosker GL, Lamb HM (July 1999). "Diclofenac/misoprostol. Pharmacoeconomic implications of therapy". PharmacoEconomics. 16 (1): 85–98. doi:10.2165/00019053-199916010-00008. PMID 10539124. S2CID 209146468.