Dicycloverine

Dicycloverine
Clinical data
Trade namesByclomine, Bentyl, Dibent, others
AHFS/Drugs.comMonograph
MedlinePlusa684007
License data
Pregnancy
category
  • AU: B1
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding>99%
Elimination half-life5 h
Identifiers
  • 2-(Diethylamino)ethyl 1-cyclohexylcyclohexane-1-carboxylate
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.919 Edit this at Wikidata
Chemical and physical data
FormulaC19H35NO2
Molar mass309.494 g·mol−1
3D model (JSmol)
  • O=C(OCCN(CC)CC)C1(CCCCC1)C2CCCCC2
  • InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3 checkY
  • Key:CURUTKGFNZGFSE-UHFFFAOYSA-N checkY
  (verify)

Dicycloverine, also known as dicyclomine, sold under the brand name Bentyl among others, is a medication that is used to treat spasms of the intestines such as those that occur in irritable bowel syndrome.[1][2] It is taken by mouth or by injection into a muscle.[2] While it has been used in baby colic and enterocolitis, evidence does not support these uses.[2]

Common side effects include dry mouth, blurry vision, weakness, sleepiness, and lightheadedness.[2] Serious side effects may include psychosis and breathing problems in babies.[2] Use in pregnancy appears to be safe while use during breastfeeding is not recommended.[3] How it works is not entirely clear.[2]

Dicycloverine was approved for medical use in the United States in 1950.[2] It is available as a generic medication.[1] In 2022, it was the 176th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[4][5]

  1. ^ a b British national formulary : BNF 76 (76 ed.). Pharmaceutical Press. 2018. p. 759. ISBN 9780857113382.
  2. ^ a b c d e f g "Dicyclomine Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
  3. ^ "Dicyclomine Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  4. ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
  5. ^ "Dicyclomine Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.