Diego de los Reyes y Balmaseda (fl. 1690–1733) was the Governor of Paraguay from February 5, 1717 to August 20, 1721. His governorship was deeply unpopular with the inhabitants of Asunción, and an investigation by judge José de Antequera y Castro of the Real Audiencia of Charcas concluded that Reyes had abused his office, and he was deposed. Antequera took the governorship of Paraguay upon himself afterward, the beginning of the Revolt of the Comuneros. Reyes never recovered his governorship, and was eventually exiled from the province after a year-long imprisonment.