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Other names | DEC, N, N-diethyl-4-methyl-1-piperazine carboxamide |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
Routes of administration | By mouth |
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ECHA InfoCard | 100.001.840 |
Chemical and physical data | |
Formula | C10H21N3O |
Molar mass | 199.298 g·mol−1 |
3D model (JSmol) | |
Melting point | 47 to 49 °C (117 to 120 °F) |
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Diethylcarbamazine is a medication used in the treatment of filariasis including lymphatic filariasis, tropical pulmonary eosinophilia, and loiasis.[1] It may also be used for prevention of loiasis in those at high risk.[1] While it has been used for onchocerciasis (river blindness), ivermectin is preferred.[2] It is taken by mouth.[3]
Common side effects include itching, facial swelling, headaches, and feeling tired.[3] Other side effects include vision loss and dizziness.[3] It is a recommended treatment in pregnancy and appears to be safe for the baby.[4][5] The World Health Organization; however, recommends waiting until after pregnancy for treatment when feasible.[2] It is made from 4-methyl-piperazine.[6]
Diethylcarbamazine was discovered in 1947[7] by Yellapragada Subbarow.[8][9] It is on the World Health Organization's List of Essential Medicines.[10] It is not commercially available in the United States but can be acquired from the Centers for Disease Control and Prevention.[1]