Diflunisal

Diflunisal
Clinical data
Trade names	Dolobid
AHFS/Drugs.com	Monograph
MedlinePlus	a684037
Pregnancy; category	AU: C; ;
Routes of; administration	By mouth
ATC code	N02BA11 (WHO) ;
Legal status
Legal status	AU: S4 (Prescription only); UK: POM (Prescription only); US: WARNINGRx-only;
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	>99%
Metabolism	Hepatic
Elimination half-life	8 to 12 hours
Excretion	Renal
Identifiers
	IUPAC name 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid;
CAS Number	22494-42-4 ;
PubChem CID	3059;
IUPHAR/BPS	7162;
DrugBank	DB00861 ;
ChemSpider	2951 ;
UNII	7C546U4DEN;
KEGG	D00130 ;
ChEBI	CHEBI:39669 ;
ChEMBL	ChEMBL898 ;
PDB ligand	1FL (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID5022932 ;
ECHA InfoCard	100.040.925
Chemical and physical data
Formula	C13H8F2O3
Molar mass	250.201 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)c1cc(ccc1O)c2ccc(F)cc2F;
	InChI InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18) ; Key:HUPFGZXOMWLGNK-UHFFFAOYSA-N ;
	(verify)

Diflunisal is a salicylic acid derivative with analgesic and anti-inflammatory activity.^[2] It was developed by Merck Sharp & Dohme in 1971, as MK647, after showing promise in a research project studying more potent chemical analogs of aspirin.^[3] It was first sold under the brand name Dolobid, marketed by Merck & Co., but generic versions are now widely available. It is classed as a nonsteroidal anti-inflammatory drug (NSAID) and is available in 250 mg and 500 mg tablets.

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
^ Boullard O, Leblanc H, Besson B (2012). "Salicylic Acid". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a23_477. ISBN 3527306730.
^ Adams SS (1999). "Ibuprofen, the propionics and NSAIDs: personal reflections over four decades". Inflammopharmacology. 7 (3): 191–7. doi:10.1007/s10787-999-0002-3. PMID 17638090. S2CID 11074565.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.

[2] Boullard O, Leblanc H, Besson B (2012). "Salicylic Acid". Ullmann's Encyclopedia of Industrial Chemistry. Weinheim: Wiley-VCH. doi:10.1002/14356007.a23_477. ISBN 3527306730.

[3] Adams SS (1999). "Ibuprofen, the propionics and NSAIDs: personal reflections over four decades". Inflammopharmacology. 7 (3): 191–7. doi:10.1007/s10787-999-0002-3. PMID 17638090. S2CID 11074565.

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