| Dihydroorotate oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Dihydroorotate dehydrogenase monomer + inhibitor, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.3.5.2 | ||||||||
| CAS no. | 9029-03-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
 Dihydroorotate dehydrogenase from E. coli | |||||||||
| Identifiers | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Symbol | DHO_dh | ||||||||
| Pfam | PF01180 | ||||||||
| InterPro | IPR001295 | ||||||||
| PROSITE | PDOC00708 | ||||||||
| SCOP2 | 1dor / SCOPe / SUPFAM | ||||||||
| OPM superfamily | 56 | ||||||||
| OPM protein | 1uum | ||||||||
| CDD | cd02810 | ||||||||
| Membranome | 250 | ||||||||
| |||||||||
| Human dihydroorotate dehydrogenase | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | DHODH | ||||||
| NCBI gene | 1723 | ||||||
| HGNC | 2867 | ||||||
| OMIM | 126064 | ||||||
| PDB | 1D3G | ||||||
| RefSeq | NM_001361 | ||||||
| UniProt | Q02127 | ||||||
| Other data | |||||||
| EC number | 1.3.3.1 | ||||||
| Locus | Chr. 16 q22 | ||||||
| |||||||
Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane (IMM).[1] Inhibitors of this enzyme are used to treat autoimmune diseases such as rheumatoid arthritis.[2]
- ^ "Entrez Gene: DHODH dihydroorotate dehydrogenase (quinone)".
- ^ Munier-Lehmann H, Vidalain PO, Tangy F, Janin YL (Apr 2013). "On dihydroorotate dehydrogenases and their inhibitors and uses". Journal of Medicinal Chemistry. 56 (8): 3148–67. doi:10.1021/jm301848w. PMID 23452331.