A 3He/4He dilution refrigerator is a cryogenic device that provides continuous cooling to temperatures as low as 2 mK, with no moving parts in the low-temperature region.[1][2] The cooling power is provided by the heat of mixing of the helium-3 and helium-4 isotopes.
The dilution refrigerator was first proposed by Heinz London in the early 1950s, and was experimentally realized in 1964 in the Kamerlingh Onnes Laboratorium at Leiden University.[3] The field of dilution refrigeration is reviewed by Zu et al.[4]