Diphtheria toxin

tox diphtheria toxin precursor
Cartoon representation of the diphtheria toxin protein
Identifiers
OrganismCorynebacterium diphtheriae
Symboltox
Entrez2650491
RefSeq (Prot)NP_938615
UniProtP00587
Other data
EC number2.4.2.36
Chromosomegenome: 0.19 - 0.19 Mb
Search for
StructuresSwiss-model
DomainsInterPro
Diphtheria toxin, C domain
Identifiers
SymbolDiphtheria_C
PfamPF02763
Pfam clanCL0084
InterProIPR022406
SCOP21ddt / SCOPe / SUPFAM
TCDB1.C.7
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Diphtheria toxin, T domain
Identifiers
SymbolDiphtheria_T
PfamPF02764
InterProIPR022405
SCOP21ddt / SCOPe / SUPFAM
TCDB1.C.7
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
Diphtheria toxin, R domain
Identifiers
SymbolDiphtheria_R
PfamPF01324
InterProIPR022404
SCOP21ddt / SCOPe / SUPFAM
TCDB1.C.7
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Diphtheria toxin is an exotoxin secreted mainly by Corynebacterium diphtheriae but also by Corynebacterium ulcerans and Corynebacterium pseudotuberculosis, the pathogenic bacterium that causes diphtheria. The toxin gene is encoded by a prophage[annotation 1] called corynephage β.[1][2] The toxin causes the disease in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis.[3]


Cite error: There are <ref group=annotation> tags on this page, but the references will not show without a {{reflist|group=annotation}} template (see the help page).

  1. ^ TABLE 1. Bacterial virulence properties altered by bacteriophages from Wagner PL, Waldor MK (August 2002). "Bacteriophage control of bacterial virulence". Infection and Immunity. 70 (8): 3985–93. doi:10.1128/IAI.70.8.3985-3993.2002. PMC 128183. PMID 12117903.
  2. ^ Johnson LP, Tomai MA, Schlievert PM (May 1986). "Bacteriophage Involvement in Group A Streptococcal Pyrogenic Exotoxin A Production". Journal of Bacteriology. 166 (2): 623–7. doi:10.1128/jb.166.2.623-627.1986. PMC 214650. PMID 3009415.
  3. ^ Bell CE, Eisenberg D (January 1996). "Crystal structure of diphtheria toxin bound to nicotinamide adenine dinucleotide". Biochemistry. 35 (4): 1137–49. doi:10.1021/bi9520848. PMID 8573568.