DnaQ

DNA pol III epsilon subunit
Identifiers
OrganismEscherichia coli
(str. K-12 substr. MG1655)
SymboldnaQ
Entrez946441
RefSeq (Prot)NP_414751.1
UniProtP03007
Other data
EC number2.7.7.7
Chromosomegenome: 0.24 - 0.24 Mb
Search for
StructuresSwiss-model
DomainsInterPro

dnaQ is the gene encoding the ε subunit of DNA polymerase III in Escherichia coli.[1] The ε subunit is one of three core proteins in the DNA polymerase complex. It functions as a 3’→5’ DNA directed proofreading exonuclease that removes incorrectly incorporated bases during replication.[2] dnaQ may also be referred to as mutD.[3]

  1. ^ Scheuermann R, Tam S, Burgers PM, Lu C, Echols H (December 1983). "Identification of the epsilon-subunit of Escherichia coli DNA polymerase III holoenzyme as the dnaQ gene product: a fidelity subunit for DNA replication". Proceedings of the National Academy of Sciences of the United States of America. 80 (23): 7085–9. doi:10.1073/pnas.80.23.7085. PMC 389997. PMID 6359162.
  2. ^ Scheuermann RH, Echols H (December 1984). "A separate editing exonuclease for DNA replication: the epsilon subunit of Escherichia coli DNA polymerase III holoenzyme". Proceedings of the National Academy of Sciences of the United States of America. 81 (24): 7747–51. doi:10.1073/pnas.81.24.7747. PMC 392229. PMID 6393125.
  3. ^ Kornberg A, Baker T (2005). DNA Replication (2nd ed.). California: University Science Books. p. 499. ISBN 1-891389-44-0.