Douglas Hanahan

Douglas Hanahan
Douglas Hanahan in 2017 at EPFL
Born1951
Seattle, Washington
NationalityAmerican
Alma materHarvard University
Known for"The Hallmarks of Cancer"
"DH5-Alpha Cell" named after him
Scientific career
InstitutionsÉcole polytechnique fédérale de Lausanne (EPFL)
University of California, San Francisco

Douglas Hanahan (born 1951)[1] is an American biologist, professor and director emeritus of the Swiss Institute for Experimental Cancer Research at EPFL (École polytechnique Fédérale de Lausanne) in Lausanne, Switzerland. He is currently member of the Lausanne branch of the Ludwig Institute.

He received his PhD from Harvard University in 1983. In 1983, he developed Super Optimal Broth, a microbiological growth medium.[2][3] He also improved the protocols used for plasmid transformation of Escherichia coli.[2] In the 1980s, he developed one of the first transgenic mouse models of cancer.[4] With Robert Weinberg, he wrote a seminal paper The Hallmarks of Cancer, published in January 2000, and which in March 2011 is the most cited article from the peer reviewed journal Cell.[5] In 2011, they published an updated review article entitled "Hallmarks of cancer: the next generation".[6] In 2022, Professor Hanahan published another updated review article, entitled "Hallmarks of Cancer: New Dimensions", in the peer reviewed journal Cancer Discovery.[7]

  1. ^ "Biography 34: Doug Hanahan (1951 - )". Dolan DNA Learning Center. Cold Spring Harbor Laboratory. Retrieved 4 April 2011.
  2. ^ a b Hanahan D (June 1983). "Studies on transformation of Escherichia coli with plasmids". Journal of Molecular Biology. 166 (4): 557–580. doi:10.1016/S0022-2836(83)80284-8. PMID 6345791.
  3. ^ "SOC Medium". Sigma-Aldrich. Merck KGaA.
  4. ^ "Douglas Hanahan". Fellows of the AACR Academy. American Association for Cancer Research (AACR).
  5. ^ Hanahan D, Weinberg RA (January 2000). "The hallmarks of cancer". Cell. 100 (1): 57–70. doi:10.1016/S0092-8674(00)81683-9. PMID 10647931. S2CID 1478778.
  6. ^ Hanahan D, Weinberg RA (March 2011). "Hallmarks of cancer: the next generation". Cell. 144 (5): 646–674. doi:10.1016/j.cell.2011.02.013. PMID 21376230.
  7. ^ Hanahan D (January 2022). "Hallmarks of Cancer: New Dimensions". Cancer Discovery. 12 (1): 31–46. doi:10.1158/2159-8290.CD-21-1059. PMID 35022204.