Submission declined on 24 July 2024 by Mgp28 (talk).
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OrthoRep is a hypermutation system used for the directed evolution of proteins. It was developed by the group of Chang C. Liu at the University of California, Irvine. It is one of the methods used for in vivo continuous evolution, which aims to expand the depth and scale in the evolutionary search for highly efficient proteins compared to conventional directed evolution. The method is based on a natural plasmid system in Kluveromyces lactis, which was ported to Saccharomyces cerevisiae, creating an extrachromosomal orthogonal error-prone replication system in yeast.[1]
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