| Submission declined on 6 October 2024 by Graeme Bartlett (talk). This submission is not adequately supported by reliable sources. Reliable sources are required so that information can be verified. If you need help with referencing, please see Referencing for beginners and Citing sources.
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| Submission declined on 23 August 2024 by Remsense (talk). This submission is not adequately supported by reliable sources. Reliable sources are required so that information can be verified. If you need help with referencing, please see Referencing for beginners and Citing sources. This submission does not appear to be written in the formal tone expected of an encyclopedia article. Entries should be written from a neutral point of view, and should refer to a range of independent, reliable, published sources. Please rewrite your submission in a more encyclopedic format. Please make sure to avoid peacock terms that promote the subject. Declined by Remsense 2 months ago. | |
Comment: Although there are medical review articles listed as references (ref 2,4,5,6), these are just on the topic of MAO inhibitors, and do not mention "Sarmentosin". So most of this article appears as a synthesis or original research. One important aspect, the toxicity is missing from this page. reference 4 used to reference the cancer statement does not mention cancer. So more suitable references will beed to be used to support most of this draft. Graeme Bartlett (talk) 22:18, 6 October 2024 (UTC)
- Comment: An infobox with the CAS number would be helpful. Robert McClenon (talk) 05:04, 1 October 2024 (UTC)
- Comment: Add links to related articles, including plant species. Add a link to and a comment about Sedum lanceolatum. Robert McClenon (talk) 04:26, 1 October 2024 (UTC)
- Comment: The DOIs are broken. Many of these are medical claims that require additional scrutiny per WP:MEDRS before they can be published. Remsense ‥ 论 09:02, 23 August 2024 (UTC)
| Names | |
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| IUPAC name
(E)-2-(hydroxymethyl)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybut-2-enenitrile
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| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChemSpider | |
| KEGG | |
PubChem CID
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| Properties | |
| C11H17NO7 | |
| Molar mass | 275.257 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Sarmentosin is a glycoside and a natural product primarily derived from several plant species, notably Ribes nigrum (blackcurrants):[1] and Rhodiola sacra.[2] It has gained attention for its potential therapeutic applications, including recently as an inhibitor of monoamine oxidase (MAO), an enzyme involved in the metabolism of neurotransmitters.[1] Research has highlighted the ability of sarmentosin to inhibit MAO-B, a subtype of the enzyme, suggesting its role in managing conditions related to monoamine neurotransmitter levels.
- ^ a b Lomiwes, D.; Günther, C. S.; Bloor, S. J.; Trower, T. M.; Ngametua, N.; Kanon, A. P.; Jensen, D. A.; Lo, K.; Sawyer, G.; Walker, E. G.; Hedderley, D.; Cooney, J. M. (2024). "Identification of Sarmentosin as a Key Bioactive from Blackcurrants (Ribes nigrum) for Inhibiting Platelet Monoamine Oxidase in Humans". Journal of Agricultural and Food Chemistry. 72 (30): 16777–16789. doi:10.1021/acs.jafc.4c03802. PMC 11299169. PMID 39028868.
- ^ Ohsugi, M; Fan, W; Xiong, Q; Tezuka, Y; Komatsu, K (1999). "Active-oxygen scavenging activity of traditional nourishing-tonic herbal medicines and active constituents of Rhodiola sacra. J Ethnopharmacol 1999;67(1):111–9". Journal of Ethnopharmacology. 67 (1): 111–119. doi:10.1016/s0378-8741(98)00245-1. PMID 10616967.