Chemical compound
Drotaverine Trade names No-Spa, Doverin AHFS /Drugs.com International Drug Names Routes of administration Oral, intravenous , intramuscular ATC code Legal status
OTC (tablets), Rx-only (solution for injection) (RU ) [ 1]
Bioavailability Highly variable (~65%), peak at 45–60 min Protein binding 95–98% Metabolism Hepatic Elimination half-life 7–16 hours Excretion >50% in urine and ~30% in bile[ 1]
(Z )-1-(3,4-diethoxybenzylidene)-6,7-diethoxy-1,2,3,4-tetrahydroisoquinoline
CAS Number PubChem CID DrugBank ChemSpider UNII KEGG ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.110.916 Formula C 24 H 31 N O 4 Molar mass 397.515 g·mol−1 3D model (JSmol )
O(c1ccc(cc1OCC)\C=C3\c2c(cc(OCC)c(OCC)c2)CCN3)CC
InChI=1S/C24H31NO4/c1-5-26-21-10-9-17(14-22(21)27-6-2)13-20-19-16-24(29-8-4)23(28-7-3)15-18(19)11-12-25-20/h9-10,13-16,25H,5-8,11-12H2,1-4H3/b20-13-
Y Key:OMFNSKIUKYOYRG-MOSHPQCFSA-N
Y
N Y (what is this?) (verify)
Drotaverine (INN , also known as drotaverin ) is an antispasmodic drug, used to enhance cervical dilation during childbirth and to relieve smooth muscle spasms in the gastrointestinal tract , urinary system , and gall bladder .[ 2] [ 3] [ 4] [ 5]
It is structurally related to papaverine , and is a selective inhibitor of phosphodiesterase-4 , and has no anticholinergic effects.[ 6]
It is available in Asia ,[specify ] Central and Eastern Europe (Poland,[ 7] Hungary,[ 8] Estonia,[ 9] Latvia,[ 10] Lithuania[ 11] ) under several brand names.[ 12] A popular brand is No-Spa, owned by Sanofi ). It is distributed by Sanofi as Но-Шпа (No-shpa) in Russia.[ 13]
^ a b "Инструкция по применению препарата Но-шпа // No-Spa (tablets) Full Prescribing Information" . National Register of Drugs (in Russian). Chinoin Pharmaceutical and Chemical Works. pp. 3–8.
^ Padubidri V, Anand E (2006). Title Textbook of Obstetrics . BI Publications Pvt Ltd. p. 283. ISBN 9788172252236 .
^ Singh KC, Jain P, Goel N, Saxena A (January 2004). "Drotaverine hydrochloride for augmentation of labor". International Journal of Gynaecology and Obstetrics . 84 (1): 17–22. doi :10.1016/s0020-7292(03)00276-5 . PMID 14698825 . S2CID 43824027 .
^ "DROTAVERINE: Uses, Side Effects and Medicines | Apollo Pharmacy" . www.apollopharmacy.in . Retrieved 2022-05-24 .
^ Cite error: The named reference :0
was invoked but never defined (see the help page ).
^ "The DrugBank database: Drotaverine" . DrugBank Version 4.1 . The Metabolomics Innovation Centre. Retrieved 9 August 2014 .
^ "No-Spa, 40 mg, tabletki, 20 szt" . doz.pl (in Polish). Retrieved 2023-01-09 .
^ "DROTAVERIN-CHINOIN 40 mg tabletta 24 db - PATIKA24 Gyógyszer" . www.patika24.hu (in Hungarian). Retrieved 2023-01-09 .
^ "NO-SPA ÕHUKE POLÜMEERKATTEGA TBL 40MG N24 | BENU Veebiap" . www.benu.ee (in Ewe). Retrieved 2023-01-09 .
^ "NO-SPA 40 mg tabletes, 24 gab. - Piegāde visā Latvijā | Mēness aptieka" . www.e-menessaptieka.lv (in Latvian). Retrieved 2023-01-09 .
^ "Drotaverine - Vaistai.lt" . vaistai.lt . Retrieved 2023-01-09 .
^ Drotaverine - Drugs.com Drugs.com international listings for drotaverine Page accessed June 28, 2015
^ "Но-шпа — инструкция по применению, дозы, побочные действия, отзывы о препарате: таблетки, покрытые пленочной оболочкой,таблетки,раствор для внутривенного и внутримышечного введения, 20 мг/мл, 40 мг, 40 мг" . РЛС® (in Russian). Retrieved 2023-10-26 .