Drumelzier (/drəˈmɛljər/), is a village and civil parish on the B712 in the Tweed Valley in the Scottish Borders.
The area of the village is extensive and includes the settlements of Wrae, Stanhope, Mossfennan and Kingledoors. To the north is Broughton and to the south the road passes Crook Inn to Tweedsmuir. Powsail Burn (also called Drumelzier Burn) runs through Drumelzier to become a tributary of the River Tweed. Stobo Castle hotel and health spa are in the area, as is Dawyck Botanic Garden, one of three "Regional Gardens" of the Royal Botanic Garden Edinburgh.