Duffy antigen system

ACKR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NUU, 4NUV
Identifiers
Aliases	ACKR1, atypical chemokine receptor 1 (Duffy blood group), CCBP1, CD234, Dfy, FY, GPD, GpFy, WBCQ1, DARC, DARC/ACKR1
External IDs	OMIM: 613665; MGI: 1097689; HomoloGene: 48067; GeneCards: ACKR1; OMA:ACKR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	159,206,500 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	173,161,317 bp
RNA expression pattern
	Top expressed in
	vena cava; ; left uterine tube; ; gastric mucosa; ; subcutaneous adipose tissue; ; pericardium; ; tibial nerve; ; olfactory zone of nasal mucosa; ; ectocervix; ; coronary artery; ; canal of the cervix;
	Top expressed in
	cerebellar cortex; ; layer of retina; ; neural layer of retina; ; bone marrow; ; primary visual cortex; ; superior frontal gyrus; ; striatum of neuraxis; ; hippocampus proper; ; olfactory bulb; ; hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	C-C chemokine binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity; chemokine binding; protein binding; signaling receptor activity;
Cellular component	integral component of membrane; recycling endosome; endosome; plasma membrane; early endosome; membrane;
Biological process	chemokine-mediated signaling pathway; regulation of chemokine production; G protein-coupled receptor signaling pathway; defense response; inflammatory response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2532
	13349
	ENSG00000213088
	ENSMUSG00000037872
	Q16570
	Q9QUI6
	NM_002036; NM_001122951
	NM_010045
	NP_001116423; NP_002027
	NP_034175
	Wikidata
View/Edit Human	View/Edit Mouse

Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the ACKR1 gene.^[5]^[6]^[7]

The Duffy antigen is located on the surface of red blood cells, and is named after the patient in whom it was discovered. The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The protein is also the receptor for the human malarial parasites Plasmodium vivax, Plasmodium knowlesi and simian malarial parasite Plasmodium cynomolgi.^[8] Polymorphisms in this gene are the basis of the Duffy blood group system.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213088 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037872 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "ACKR1 gene". U.S. National Library of Medicine Genetics Home Reference. August 17, 2020. Retrieved September 9, 2020.
^ Chaudhuri A, Polyakova J, Zbrzezna V, Williams K, Gulati S, Pogo AO (November 1993). "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10793–7. Bibcode:1993PNAS...9010793C. doi:10.1073/pnas.90.22.10793. PMC 47864. PMID 8248172.
^ Tournamille C, Colin Y, Cartron JP, Le Van Kim C (June 1995). "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals". Nat. Genet. 10 (2): 224–8. doi:10.1038/ng0695-224. PMID 7663520. S2CID 7125832.
^ Kosaisavee V, Suwanarusk R, Chua AC, Kyle DE, Malleret B, Zhang R, Imwong M, Imerbsin R, Ubalee R, Sámano-Sánchez H, Yeung BK, Ong JJ, Lombardini E, Nosten F, Tan KS, Bifani P, Snounou G, Rénia L, Russell B (September 2017). "Strict tropism for CD71+/CD234+human reticulocytes limits the zoonotic potential ofPlasmodium cynomolgi". Blood. 130 (11): 1357–1363. doi:10.1182/blood-2017-02-764787. PMC 5600141. PMID 28698207.
^ "Entrez Gene: Duffy antigen".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213088 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037872 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "ACKR1 gene". U.S. National Library of Medicine Genetics Home Reference. August 17, 2020. Retrieved September 9, 2020.

[pmid8248172-6] Chaudhuri A, Polyakova J, Zbrzezna V, Williams K, Gulati S, Pogo AO (November 1993). "Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite". Proc. Natl. Acad. Sci. U.S.A. 90 (22): 10793–7. Bibcode:1993PNAS...9010793C. doi:10.1073/pnas.90.22.10793. PMC 47864. PMID 8248172.

[pmid7663520-7] Tournamille C, Colin Y, Cartron JP, Le Van Kim C (June 1995). "Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals". Nat. Genet. 10 (2): 224–8. doi:10.1038/ng0695-224. PMID 7663520. S2CID 7125832.

[pmid28698207-8] Kosaisavee V, Suwanarusk R, Chua AC, Kyle DE, Malleret B, Zhang R, Imwong M, Imerbsin R, Ubalee R, Sámano-Sánchez H, Yeung BK, Ong JJ, Lombardini E, Nosten F, Tan KS, Bifani P, Snounou G, Rénia L, Russell B (September 2017). "Strict tropism for CD71+/CD234+human reticulocytes limits the zoonotic potential ofPlasmodium cynomolgi". Blood. 130 (11): 1357–1363. doi:10.1182/blood-2017-02-764787. PMC 5600141. PMID 28698207.

[entrez_2532-9] "Entrez Gene: Duffy antigen".

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