| Duke William of Mecklenburg-Schwerin | |||||
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| Born | 5 March 1827 Ludwigslust | ||||
| Died | 28 July 1879 (aged 52) Heidelberg | ||||
| Spouse | Alexandrine of Prussia | ||||
| Issue | Duchess Charlotte | ||||
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| House | House of Mecklenburg-Schwerin | ||||
| Father | Paul Frederick, Grand Duke of Mecklenburg-Schwerin | ||||
| Mother | Alexandrine of Prussia | ||||
Duke Frederick William Nicholas of Mecklenburg-Schwerin (German: Friedrich Wilhelm Nicolas; 5 March 1827 – 28 July 1879) was the second son of Paul Frederick, Grand Duke of Mecklenburg-Schwerin, and his wife Princess Alexandrine, daughter of King Frederick William III of Prussia.