E-selectin

SELE
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1ESL, 1G1T, 4C16, 4CSY
Identifiers
Aliases	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2, selectin E, selectin-e
External IDs	OMIM: 131210; MGI: 98278; HomoloGene: 389; GeneCards: SELE; OMA:SELE - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	169,764,705 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	163,885,246 bp
RNA expression pattern
	Top expressed in
	vena cava; ; left uterine tube; ; testicle; ; seminal vesicula; ; olfactory zone of nasal mucosa; ; trachea; ; gastric mucosa; ; cartilage tissue; ; mucosa of urinary bladder; ; gallbladder;
	Top expressed in
	transitional epithelium of urinary bladder; ; spermatid; ; spermatocyte; ; granulocyte; ; endothelial cell of lymphatic vessel; ; intestinal villus; ; semi-lunar valve; ; Ileal epithelium; ; atrioventricular valve; ; lip;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phospholipase binding; oligosaccharide binding; protein binding; transmembrane signaling receptor activity; carbohydrate binding; sialic acid binding; metal ion binding;
Cellular component	integral component of membrane; membrane; cortical cytoskeleton; plasma membrane; perinuclear region of cytoplasm; caveola; membrane raft; clathrin-coated pit; extracellular space; integral component of plasma membrane;
Biological process	leukocyte cell-cell adhesion; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; response to interleukin-1; positive regulation of receptor internalization; actin filament-based process; leukocyte migration involved in inflammatory response; activation of phospholipase C activity; response to tumor necrosis factor; response to lipopolysaccharide; cell adhesion; regulation of inflammatory response; leukocyte tethering or rolling; inflammatory response; leukocyte migration; calcium-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	6401
	20339
	ENSG00000007908
	ENSMUSG00000026582
	P16581
	Q00690
	NM_000450
	NM_011345
	NP_000441
	NP_035475
	Wikidata
View/Edit Human	View/Edit Mouse

E-selectin, also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a selectin cell adhesion molecule expressed only on endothelial cells activated by cytokines. Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007908 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026582 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Collins T, Williams A, Johnston GI, Kim J, Eddy R, Shows T, et al. (February 1991). "Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1". The Journal of Biological Chemistry. 266 (4): 2466–73. doi:10.1016/S0021-9258(18)52267-5. PMID 1703529.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007908 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026582 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1703529-5] Collins T, Williams A, Johnston GI, Kim J, Eddy R, Shows T, et al. (February 1991). "Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1". The Journal of Biological Chemistry. 266 (4): 2466–73. doi:10.1016/S0021-9258(18)52267-5. PMID 1703529.

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