ECHS1

ECHS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HW5
Identifiers
Aliases	ECHS1, SCEH, ECHS1D, enoyl-CoA hydratase, short chain, 1, mitochondrial, enoyl-CoA hydratase, short chain 1, mECH, mECH1
External IDs	OMIM: 602292; MGI: 2136460; HomoloGene: 3018; GeneCards: ECHS1; OMA:ECHS1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	133,373,354 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,696,389 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney tubule; ; parotid gland; ; human kidney; ; mucosa of transverse colon; ; jejunal mucosa; ; renal medulla; ; glomerulus; ; apex of heart; ; metanephric glomerulus;
	Top expressed in
	brown adipose tissue; ; right ventricle; ; right kidney; ; left lobe of liver; ; myocardium of ventricle; ; digastric muscle; ; interventricular septum; ; cardiac muscles; ; adrenal gland; ; white adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; catalytic activity; lyase activity; enoyl-CoA hydratase activity;
Cellular component	mitochondrial matrix; mitochondrion;
Biological process	metabolism; fatty acid metabolic process; lipid metabolism; fatty acid beta-oxidation;
	Sources:Amigo / QuickGO
Orthologs
	1892
	93747
	ENSG00000127884
	ENSMUSG00000025465
	P30084
	Q8BH95
	NM_004092
	NM_053119
	NP_004083
	NP_444349
	Wikidata
View/Edit Human	View/Edit Mouse

Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial, also known as ECHS1, is a human gene.^[5]

The protein encoded by this gene functions in the second step of the mitochondrial fatty acid beta-oxidation pathway. It catalyzes the hydration of 2-trans-enoyl-coenzyme A (CoA) intermediates to L-3-hydroxyacyl-CoAs. The gene product is a member of the hydratase/isomerase superfamily. It localizes to the mitochondrial matrix. Transcript variants utilizing alternative transcription initiation sites have been described in the literature.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127884 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025465 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: ECHS1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127884 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025465 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: ECHS1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial".

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