EIF1

EIF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IF1, 4KZX, 4KZY
Identifiers
Aliases	EIF1, A121, EIF-1, ISO1, SUI1, eukaryotic translation initiation factor 1, Eukaryotic initiation factor 1
External IDs	MGI: 105125; HomoloGene: 130538; GeneCards: EIF1; OMA:EIF1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	41,692,668 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	100,212,922 bp
RNA expression pattern
	Top expressed in
	sperm; ; oocyte; ; parotid gland; ; parietal pleura; ; tail of epididymis; ; lower lobe of lung; ; secondary oocyte; ; vena cava; ; caput epididymis; ; visceral pleura;
	Top expressed in
	granulocyte; ; muscle of thigh; ; morula; ; blastocyst; ; superior frontal gyrus; ; right kidney; ; ventricular zone; ; neural tube; ; extensor digitorum longus muscle; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation factor activity, RNA binding; translation initiation factor activity; RNA binding; protein binding; ribosomal small subunit binding;
Cellular component	cytoplasm; nucleus; eukaryotic 43S preinitiation complex;
Biological process	translational initiation; response to stress; dosage compensation by inactivation of X chromosome; protein biosynthesis; regulation of translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	10209
	20918
	ENSG00000173812
	ENSMUSG00000035530
	P41567
	P48024
	NM_005801
	NM_011508
	NP_005792
	NP_035638
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 1 (eIF1) is a protein that in humans is encoded by the EIF1 gene. It is related to yeast SUI1.^[5]^[6]^[7]

eIF1 interacts with the eukaryotic small (40S) ribosomal subunit and eIF3, and is a component of the 43S preinitiation complex (PIC).^[8] eIF1 and eIF1A bind cooperatively to the 40S to stabilize an "open" conformation of the preinitiation complex (PIC) during eukaryotic translation initiation.^[8] eIF1 binds to a region near the ribosomal P-site in the 40S subunit and functions in a manner similar to the structurally related bacterial counterpart IF3.^[9]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173812 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035530 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fields C, Adams MD (January 1994). "Expressed sequence tags identify a human isolog of the suil translation initiation factor". Biochemical and Biophysical Research Communications. 198 (1): 288–91. doi:10.1006/bbrc.1994.1040. PMID 7904817.
^ Sheikh MS, Fernandez-Salas E, Yu M, Hussain A, Dinman JD, Peltz SW, Huang Y, Fornace AJ (June 1999). "Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1))". The Journal of Biological Chemistry. 274 (23): 16487–93. doi:10.1074/jbc.274.23.16487. PMID 10347211.
^ "Entrez Gene: EIF1 eukaryotic translation initiation factor 1".
^ ^a ^b Aitken CE, Lorsch JR (June 2012). "A mechanistic overview of translation initiation in eukaryotes". Nature Structural & Molecular Biology. 19 (6): 568–76. doi:10.1038/nsmb.2303. PMID 22664984. S2CID 9201095.
^ Fraser CS (July 2015). "Quantitative studies of mRNA recruitment to the eukaryotic ribosome". Biochimie. 114: 58–71. doi:10.1016/j.biochi.2015.02.017. PMC 4458453. PMID 25742741.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173812 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035530 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7904817-5] Fields C, Adams MD (January 1994). "Expressed sequence tags identify a human isolog of the suil translation initiation factor". Biochemical and Biophysical Research Communications. 198 (1): 288–91. doi:10.1006/bbrc.1994.1040. PMID 7904817.

[Sheikh_1999-6] Sheikh MS, Fernandez-Salas E, Yu M, Hussain A, Dinman JD, Peltz SW, Huang Y, Fornace AJ (June 1999). "Cloning and characterization of a human genotoxic and endoplasmic reticulum stress-inducible cDNA that encodes translation initiation factor 1(eIF1(A121/SUI1))". The Journal of Biological Chemistry. 274 (23): 16487–93. doi:10.1074/jbc.274.23.16487. PMID 10347211.

[entrez-7] "Entrez Gene: EIF1 eukaryotic translation initiation factor 1".

[Aitken-8] Aitken CE, Lorsch JR (June 2012). "A mechanistic overview of translation initiation in eukaryotes". Nature Structural & Molecular Biology. 19 (6): 568–76. doi:10.1038/nsmb.2303. PMID 22664984. S2CID 9201095.

[Fraser_2015-9] Fraser CS (July 2015). "Quantitative studies of mRNA recruitment to the eukaryotic ribosome". Biochimie. 114: 58–71. doi:10.1016/j.biochi.2015.02.017. PMC 4458453. PMID 25742741.

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