EIF1AX

EIF1AX
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1D7Q, 3ZJY, 4KZY, 4KZZ
Identifiers
Aliases	EIF1AX, EIF1A, EIF1AP1, EIF4C, eIF-1A, eIF-4C, eukaryotic translation initiation factor 1A, X-linked, eukaryotic translation initiation factor 1A X-linked
External IDs	OMIM: 300186; MGI: 95298; HomoloGene: 20364; GeneCards: EIF1AX; OMA:EIF1AX - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	20,141,838 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	46,749,523 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Skeletal muscle tissue of rectus abdominis; ; gonad; ; lateral nuclear group of thalamus; ; biceps brachii; ; pons; ; ganglionic eminence; ; pericardium; ; Skeletal muscle tissue of biceps brachii; ; postcentral gyrus;
	Top expressed in
	seminal vesicula; ; otic placode; ; saccule; ; pineal gland; ; otic vesicle; ; decidua; ; corneal stroma; ; epiblast; ; tail of embryo; ; calvaria;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	translation factor activity, RNA binding; protein binding; translation initiation factor activity; RNA binding;
Cellular component	cytosol;
Biological process	translational initiation; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	1964
	13664
	ENSG00000173674
	ENSMUSG00000057561
	P47813
	Q60872
	NM_001412
	NM_010120; NM_001374654
	NP_001403
	NP_034250
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 1A, X-chromosomal (eIF1A) is a protein that in humans is encoded by the EIF1AX gene.^[5]^[6]^[7] This gene encodes an essential eukaryotic translation initiation factor. The protein is a component of the 43S pre-initiation complex (PIC), which mediates the recruitment of the small 40S ribosomal subunit to the 5' cap of messenger RNAs.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173674 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000057561 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Feb 1994). "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing". The Journal of Biological Chemistry. 269 (5): 3212–8. doi:10.1016/S0021-9258(17)41850-3. PMID 8106356.
^ Lahn BT, Page DC (Oct 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.
^ ^a ^b "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000173674 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000057561 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8106356-5] Dever TE, Wei CL, Benkowski LA, Browning K, Merrick WC, Hershey JW (Feb 1994). "Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing". The Journal of Biological Chemistry. 269 (5): 3212–8. doi:10.1016/S0021-9258(17)41850-3. PMID 8106356.

[pmid9381176-6] Lahn BT, Page DC (Oct 1997). "Functional coherence of the human Y chromosome". Science. 278 (5338): 675–80. Bibcode:1997Sci...278..675L. doi:10.1126/science.278.5338.675. PMID 9381176.

[entrez-7] "Entrez Gene: EIF1AX eukaryotic translation initiation factor 1A, X-linked".

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