EIF2AK1

EIF2AK1
Identifiers
Aliases	EIF2AK1, HCR, HRI, eukaryotic translation initiation factor 2 alpha kinase 1, LEMSPAD, hHRI
External IDs	OMIM: 613635; MGI: 1353448; HomoloGene: 8290; GeneCards: EIF2AK1; OMA:EIF2AK1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	6,059,175 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	143,841,069 bp
RNA expression pattern
	Top expressed in
	trabecular bone; ; monocyte; ; parotid gland; ; islet of Langerhans; ; ventricular zone; ; bone marrow; ; mucosa of ileum; ; bone marrow cells; ; stromal cell of endometrium; ; rectum;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; secondary oocyte; ; tibiofemoral joint; ; maxillary prominence; ; mandibular prominence; ; bone marrow; ; primary oocyte; ; right kidney; ; tail of embryo; ; epithelium of stomach;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; kinase activity; protein serine/threonine kinase activity; ATP binding; heme binding; protein homodimerization activity; eukaryotic translation initiation factor 2alpha kinase activity; translation initiation factor activity;
Cellular component	cytoplasm;
Biological process	negative regulation of translation; phosphorylation; regulation of hemoglobin biosynthetic process; iron ion homeostasis; macrophage differentiation; protein phosphorylation; regulation of translational initiation by eIF2 alpha phosphorylation; acute inflammatory response; protoporphyrinogen IX metabolic process; regulation of eIF2 alpha phosphorylation by heme; phagocytosis; negative regulation of translational initiation by iron; regulation of translation; negative regulation of cell population proliferation; protein autophosphorylation; negative regulation of hemoglobin biosynthetic process; response to iron ion starvation; translational initiation;
	Sources:Amigo / QuickGO
Orthologs
	27102
	15467
	ENSG00000086232
	ENSMUSG00000029613
	Q9BQI3
	Q9Z2R9
	NM_014413; NM_001134335
	NM_013557
	NP_001127807; NP_055228; NP_055228.2
	NP_038585
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 2-alpha kinase 1 is an enzyme that in humans is encoded by the EIF2AK1 gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000086232 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029613 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen JJ, London IM (May 1995). "Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase". Trends Biochem Sci. 20 (3): 105–8. doi:10.1016/S0968-0004(00)88975-6. PMID 7709427.
^ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
^ "Entrez Gene: EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000086232 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029613 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7709427-5] Chen JJ, London IM (May 1995). "Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase". Trends Biochem Sci. 20 (3): 105–8. doi:10.1016/S0968-0004(00)88975-6. PMID 7709427.

[pmid10718198-6] Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.

[entrez-7] "Entrez Gene: EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1".

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