EIF2S1

EIF2S1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1KL9, 1Q8K
Identifiers
Aliases	EIF2S1, EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, eukaryotic translation initiation factor 2 subunit alpha
External IDs	OMIM: 603907; MGI: 95299; HomoloGene: 3020; GeneCards: EIF2S1; OMA:EIF2S1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	67,386,516 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	78,933,784 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; monocyte; ; gingival epithelium; ; gastrocnemius muscle; ; ganglionic eminence; ; stromal cell of endometrium; ; right ventricle; ; appendix; ; ventricular zone; ; body of pancreas;
	Top expressed in
	embryo; ; embryo; ; morula; ; morula; ; blastocyst; ; tail of embryo; ; ventricular zone; ; genital tubercle; ; right kidney; ; corneal stroma;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; ribosome binding; protein binding; nucleic acid binding; RNA binding;
Cellular component	cytoplasm; eukaryotic 48S preinitiation complex; polysome; cytosol; ribosome; membrane; multi-eIF complex; eukaryotic translation initiation factor 2B complex; glial limiting end-foot; translation initiation ternary complex; cytoplasmic stress granule; extracellular exosome; nucleus; eukaryotic translation initiation factor 2 complex; synapse;
Biological process	cellular response to heat; positive regulation of type B pancreatic cell apoptotic process; negative regulation of translational initiation in response to stress; cellular response to UV; cellular response to amino acid starvation; human ageing; response to endoplasmic reticulum stress; PERK-mediated unfolded protein response; response to manganese-induced endoplasmic reticulum stress; transmembrane transport; translational initiation; protein autophosphorylation; regulation of translation; regulation of translational initiation in response to stress; negative regulation of guanyl-nucleotide exchange factor activity; positive regulation of neuron death; protein biosynthesis; stress granule assembly; cellular response to oxidative stress;
	Sources:Amigo / QuickGO
Orthologs
	1965
	13665
	ENSG00000134001
	ENSMUSG00000021116
	P05198
	Q6ZWX6
	NM_004094
	NM_026114
	NP_004085
	NP_080390
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 2 subunit 1 (eIF2α) is a protein that in humans is encoded by the EIF2S1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000134001 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021116 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ernst H, Duncan RF, Hershey JW (January 1987). "Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA". The Journal of Biological Chemistry. 262 (3): 1206–12. doi:10.1016/S0021-9258(19)75772-X. PMID 2948954.
^ "Entrez Gene: EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa". National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2010-10-05.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000134001 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021116 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2948954-5] Ernst H, Duncan RF, Hershey JW (January 1987). "Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA". The Journal of Biological Chemistry. 262 (3): 1206–12. doi:10.1016/S0021-9258(19)75772-X. PMID 2948954.

[entrez-6] "Entrez Gene: EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa". National Center for Biotechnology Information, U.S. National Library of Medicine. Retrieved 2010-10-05.

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