EIF4E

EIF4E
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1IPB, 1IPC, 1WKW, 2GPQ, 2V8W, 2V8X, 2V8Y, 2W97, 3AM7, 3TF2, 3U7X, 4AZA, 4BEA, 4DT6, 4DUM, 4TPW, 4TQB, 4TQC, 4UED, 5ABI
Identifiers
Aliases	EIF4E, eukaryotic translation initiation factor 4E, AUTS19, CBP, EIF4E1, EIF4EL1, EIF4F, eIF-4E
External IDs	OMIM: 133440; MGI: 95305; HomoloGene: 123817; GeneCards: EIF4E; OMA:EIF4E - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	98,929,133 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	138,265,457 bp
RNA expression pattern
	Top expressed in
	sperm; ; Achilles tendon; ; oocyte; ; ventricular zone; ; ganglionic eminence; ; secondary oocyte; ; right testis; ; rectum; ; left testis; ; epithelium of colon;
	Top expressed in
	neural layer of retina; ; morula; ; tail of embryo; ; genital tubercle; ; ventricular zone; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; embryo; ; muscle of thigh; ; superior frontal gyrus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; eukaryotic initiation factor 4G binding; protein binding; enzyme binding; RNA cap binding; RNA 7-methylguanosine cap binding; RNA binding; translation regulator activity;
Cellular component	cytoplasm; chromatoid body; RISC complex; P-body; mRNA cap binding complex; perinuclear region of cytoplasm; cytoplasmic stress granule; eukaryotic translation initiation factor 4F complex; extracellular exosome; cytosol; cytoplasmic ribonucleoprotein granule; protein-containing complex; postsynapse; glutamatergic synapse; postsynaptic cytosol;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; negative regulation of translation; negative regulation of neuron differentiation; lung development; G1 phase; positive regulation of mitotic cell cycle; behavioral fear response; mRNA export from nucleus; stem cell population maintenance; translational initiation; viral process; regulation of translation; RNA export from nucleus; protein biosynthesis; negative regulation of autophagy; cellular response to dexamethasone stimulus; G1/S transition of mitotic cell cycle; regulation of translation at postsynapse, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	1977
	13684
	ENSG00000151247
	ENSMUSG00000028156
	P06730
	P63073
	NM_001130678; NM_001130679; NM_001968; NM_001331017
	NM_007917; NM_001313980
	NP_001124150; NP_001124151; NP_001317946; NP_001959
	NP_001300909; NP_031943
	Wikidata
View/Edit Human	View/Edit Mouse

4EBP (red) bound to the alpha helices (cyan) of eIF4E.

Eukaryotic translation initiation factor 4E, also known as eIF4E, is a protein that in humans is encoded by the EIF4E gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151247 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028156 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pelletier J, Brook JD, Housman DE (August 1991). "Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20". Genomics. 10 (4): 1079–82. doi:10.1016/0888-7543(91)90203-Q. PMID 1916814.
^ Jones RM, MacDonald ME, Branda J, Altherr MR, Louis DN, Schmidt EV (May 1997). "Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4". Somatic Cell and Molecular Genetics. 23 (3): 221–223. doi:10.1007/BF02721373. PMID 9330633. S2CID 10683455.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151247 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028156 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Pelletier?1991-5] Pelletier J, Brook JD, Housman DE (August 1991). "Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20". Genomics. 10 (4): 1079–82. doi:10.1016/0888-7543(91)90203-Q. PMID 1916814.

[jones1997-6] Jones RM, MacDonald ME, Branda J, Altherr MR, Louis DN, Schmidt EV (May 1997). "Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4". Somatic Cell and Molecular Genetics. 23 (3): 221–223. doi:10.1007/BF02721373. PMID 9330633. S2CID 10683455.

[1]

[2]

[3]

[4]

[5]

[6]