EIF4G2

EIF4G2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3D3M, 3L6A, 4IUL
Identifiers
Aliases	EIF4G2, AAG1, DAP5, NAT1, P97, eukaryotic translation initiation factor 4 gamma 2
External IDs	OMIM: 602325; MGI: 109207; HomoloGene: 37477; GeneCards: EIF4G2; OMA:EIF4G2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	10,808,940 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	110,682,237 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; germinal epithelium; ; parietal pleura; ; gingival epithelium; ; tibia; ; ganglionic eminence; ; epithelium of colon; ; ventricular zone; ; superficial temporal artery; ; epithelium of nasopharynx;
	Top expressed in
	tail of embryo; ; renal corpuscle; ; genital tubercle; ; Gonadal ridge; ; molar; ; Rostral migratory stream; ; conjunctival fornix; ; retinal pigment epithelium; ; ciliary body; ; migratory enteric neural crest cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	translation factor activity, RNA binding; protein binding; translation initiation factor activity; RNA binding; cadherin binding; mRNA binding;
Cellular component	cytosol; eukaryotic translation initiation factor 4F complex; membrane;
Biological process	translational initiation; cell death; protein biosynthesis; regulation of translation; regulation of translational initiation; negative regulation of autophagy; positive regulation of cell growth; cellular macromolecule biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1982
	13690
	ENSG00000110321
	ENSMUSG00000005610
	P78344
	Q62448
	NM_001418; NM_001042559; NM_001172705
	NM_001040131; NM_013507
	NP_001036024; NP_001166176; NP_001409
	NP_001035221; NP_038535
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 4 gamma 2 (also called p97, NAT1, and DAP-5) is a protein that in humans is encoded by the EIF4G2 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110321 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005610 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamanaka S, Poksay KS, Arnold KS, Innerarity TL (March 1997). "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme". Genes Dev. 11 (3): 321–33. doi:10.1101/gad.11.3.321. PMID 9030685.
^ Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A (March 1997). "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death". Mol. Cell. Biol. 17 (3): 1615–25. doi:10.1128/mcb.17.3.1615. PMC 231887. PMID 9032289.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110321 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005610 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9030685-5] Yamanaka S, Poksay KS, Arnold KS, Innerarity TL (March 1997). "A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme". Genes Dev. 11 (3): 321–33. doi:10.1101/gad.11.3.321. PMID 9030685.

[pmid9032289-6] Levy-Strumpf N, Deiss LP, Berissi H, Kimchi A (March 1997). "DAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell death". Mol. Cell. Biol. 17 (3): 1615–25. doi:10.1128/mcb.17.3.1615. PMC 231887. PMID 9032289.

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