ELOC

ELOC
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1LM8, 1LQB, 1VCB, 2C9W, 2IZV, 2MA9, 3DCG, 3ZKJ, 3ZNG, 3ZRC, 3ZRF, 3ZTC, 3ZTD, 3ZUN, 4AJY, 4AWJ, 4B95, 4B9K, 4BKS, 4BKT, 4N9F, 4W9C, 4W9D, 4W9E, 4W9F, 4W9G, 4W9H, 4W9I, 4W9J, 4W9K, 4W9L, 4WQO, 5BO4
Identifiers
Aliases	ELOC, SIII, eloC, TCEB1, transcription elongation factor B subunit 1, elongin C
External IDs	OMIM: 600788; MGI: 1915173; HomoloGene: 38083; GeneCards: ELOC; OMA:ELOC - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	73,972,307 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	16,727,266 bp
RNA expression pattern
	Top expressed in
	oocyte; ; sperm; ; right ventricle; ; gingival epithelium; ; palpebral conjunctiva; ; left testis; ; right testis; ; tendon of biceps brachii; ; biceps brachii; ; amniotic fluid;
	Top expressed in
	morula; ; primary oocyte; ; blastocyst; ; primitive streak; ; endothelial cell of lymphatic vessel; ; epithelium of stomach; ; yolk sac; ; facial motor nucleus; ; medial ganglionic eminence; ; atrioventricular valve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity;
Cellular component	cytosol; nucleus; elongin complex; nucleoplasm;
Biological process	regulation of transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription by RNA polymerase II; ubiquitin-dependent protein catabolic process; transcription, DNA-templated; regulation of transcription from RNA polymerase II promoter in response to hypoxia; viral process; positive regulation of transcription elongation from RNA polymerase II promoter; post-translational protein modification; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	6921
	67923
	ENSG00000154582
	ENSMUSG00000079658
	Q15369
	P83940
NM_001204857; NM_001204858; NM_001204859; NM_001204860; NM_001204861;
	NM_001204862; NM_001204863; NM_001204864; NM_005648
	NM_001310470; NM_026456
NP_001191786; NP_001191787; NP_001191788; NP_001191789; NP_001191790;
	NP_001191791; NP_001191792; NP_001191793; NP_005639
	NP_001297399; NP_080732
	Wikidata
View/Edit Human	View/Edit Mouse

Elongin C is a protein that in humans is encoded by the ELOC gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154582 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079658 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Garrett KP, Haque D, Conaway RC, Conaway JW (Feb 1995). "A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII". Gene. 150 (2): 413–4. doi:10.1016/0378-1119(94)90467-7. PMID 7821821.
^ Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garrett KP, Conaway RC, Conaway JW, Linehan WM, Klausner RD (Oct 1995). "Inhibition of transcription elongation by the VHL tumor suppressor protein". Science. 269 (5229): 1402–6. Bibcode:1995Sci...269.1402D. doi:10.1126/science.7660122. PMID 7660122. S2CID 22334719.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154582 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079658 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7821821-5] Garrett KP, Haque D, Conaway RC, Conaway JW (Feb 1995). "A human cDNA encoding the small subunit of RNA polymerase II transcription factor SIII". Gene. 150 (2): 413–4. doi:10.1016/0378-1119(94)90467-7. PMID 7821821.

[pmid7660122-6] Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garrett KP, Conaway RC, Conaway JW, Linehan WM, Klausner RD (Oct 1995). "Inhibition of transcription elongation by the VHL tumor suppressor protein". Science. 269 (5229): 1402–6. Bibcode:1995Sci...269.1402D. doi:10.1126/science.7660122. PMID 7660122. S2CID 22334719.

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