EML4

EML4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4CGC
Identifiers
Aliases	EML4, C2orf2, ELP120, EMAP-4, EMAPL4, ROPP120, echinoderm microtubule associated protein like 4, EMAP like 4
External IDs	OMIM: 607442; MGI: 1926048; HomoloGene: 56841; GeneCards: EML4; OMA:EML4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	42,332,548 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	83,787,790 bp
RNA expression pattern
	Top expressed in
	tibia; ; jejunal mucosa; ; visceral pleura; ; tonsil; ; mucosa of sigmoid colon; ; epithelium of nasopharynx; ; duodenum; ; rectum; ; pylorus; ; mucosa of paranasal sinus;
	Top expressed in
	hand; ; maxillary prominence; ; mandibular prominence; ; molar; ; primitive streak; ; abdominal wall; ; Gonadal ridge; ; secondary oocyte; ; migratory enteric neural crest cell; ; renal corpuscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; molecular function;
Cellular component	cytoplasm; microtubule; cytoskeleton; membrane; microtubule cytoskeleton; mitotic spindle;
Biological process	microtubule-based process; mitotic cell cycle; microtubule cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	27436
	78798
	ENSG00000143924
	ENSMUSG00000032624
	Q9HC35
	Q3UMY5
	NM_001145076; NM_019063
NM_001114361; NM_001114362; NM_001286567; NM_199466; NM_001357886;
	NM_001379373; NM_001379374
	NP_001138548; NP_061936
NP_001107833; NP_001107834; NP_001273496; NP_955760; NP_001344815;
	NP_001366302; NP_001366303
	Wikidata
View/Edit Human	View/Edit Mouse

Echinoderm microtubule-associated protein-like 4 is a protein that in humans is encoded by the EML4 gene.^[5]

This protein is involved in cancers when spliced with the anaplastic lymphoma kinase.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143924 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032624 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EML4 echinoderm microtubule associated protein like 4".
^ Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. doi:10.1158/0008-5472.CAN-07-6158. PMID 18593892.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143924 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032624 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: EML4 echinoderm microtubule associated protein like 4".

[pmid18593892-6] Choi YL, Takeuchi K, Soda M, Inamura K, Togashi Y, Hatano S, Enomoto M, Hamada T, Haruta H, Watanabe H, Kurashina K, Hatanaka H, Ueno T, Takada S, Yamashita Y, Sugiyama Y, Ishikawa Y, Mano H (July 2008). "Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer". Cancer Res. 68 (13): 4971–6. doi:10.1158/0008-5472.CAN-07-6158. PMID 18593892.

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