ENPP7

ENPP7
Identifiers
Aliases	ENPP7, ALK-SMase, E-NPP 7, NPP-7, NPP7, ectonucleotide pyrophosphatase/phosphodiesterase 7
External IDs	OMIM: 616997; MGI: 3027917; HomoloGene: 110852; GeneCards: ENPP7; OMA:ENPP7 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	79,742,219 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,884,047 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; tendon of biceps brachii; ; testicle; ; vena cava; ; liver; ; Skeletal muscle tissue of rectus abdominis; ; right lobe of liver; ; trabecular bone; ; cerebellar vermis;
	Top expressed in
	jejunum; ; placenta; ; ileum; ; yolk sac; ; blastocyst; ; duodenum; ; colon; ; stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	catalytic activity; hydrolase activity; sphingomyelin phosphodiesterase activity; zinc ion binding; metal ion binding;
Cellular component	integral component of membrane; microvillus; plasma membrane; Golgi apparatus; membrane; integral component of plasma membrane;
Biological process	metabolism; sphingomyelin catabolic process; negative regulation of DNA replication; glycosphingolipid metabolic process; negative regulation of cell population proliferation; sphingomyelin metabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
	339221
	238011
	ENSG00000182156
	ENSMUSG00000046697
	Q6UWV6
	n/a
	NM_178543
	NM_001030291; NM_001359574
	NP_848638
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) also known as alkaline sphingomyelin phosphodiesterase (Alk-SMase) or intestinal alkaline sphingomyelinase is an enzyme that in humans is encoded by the ENPP7 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182156 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046697 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Duan RD, Bergman T, Xu N, Wu J, Cheng Y, Duan J, Nelander S, Palmberg C, Nilsson A (Sep 2003). "Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family". J Biol Chem. 278 (40): 38528–36. doi:10.1074/jbc.M305437200. PMID 12885774.
^ "Entrez Gene: ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182156 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046697 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12885774-5] Duan RD, Bergman T, Xu N, Wu J, Cheng Y, Duan J, Nelander S, Palmberg C, Nilsson A (Sep 2003). "Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family". J Biol Chem. 278 (40): 38528–36. doi:10.1074/jbc.M305437200. PMID 12885774.

[entrez-6] "Entrez Gene: ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7".

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