En (Borger 2003 nr. 164 ; U+12097 𒂗, see also Ensí) is the Sumerian cuneiform for 'lord/lady' or 'priest[ess]'. Originally, it seems to have been used to designate a high priest or priestess of a Sumerian city-state's patron-deity[2] – a position that entailed political power as well. It may also have been the original title of the ruler of Uruk. See Lugal, ensi and en for more details.
Deities including En as part of their name include DEnlil, DEnki, DEngurun, and DEnzu.
Enheduanna, Akkadian 2285 BC – 2250 BC was the first known holder of the title En, here meaning 'Priestess'.