ERBB3

ERBB3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1M6B, 2L9U, 3KEX, 3LMG, 3P11, 4LEO, 4OTW, 4P59, 4RIW, 4RIX, 4RIY, 5CUS
Identifiers
Aliases	ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3, erb-b2 receptor tyrosine kinase 3, FERLK, VSCN1
External IDs	OMIM: 190151; MGI: 95411; HomoloGene: 20457; GeneCards: ERBB3; OMA:ERBB3 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.2 Start 56,076,799 bp[1] End 56,103,505 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 D3|10 77.1 cM Start 128,403,392 bp[2] End 128,425,521 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in trigeminal ganglion jejunal mucosa spinal ganglia inferior ganglion of vagus nerve corpus callosum mucosa of colon mucosa of ileum mucosa of sigmoid colon duodenum external globus pallidus Top expressed in left colon jejunum ileum intestinal villus transitional epithelium of urinary bladder lacrimal gland epidermis hair follicle conjunctival fornix sciatic nerve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity protein tyrosine kinase activator activity growth factor binding protein homodimerization activity kinase activity protein binding identical protein binding protein heterodimerization activity ATP binding transmembrane signaling receptor activity neuregulin binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein tyrosine kinase activity ubiquitin protein ligase binding receptor tyrosine kinase neuregulin receptor activity transmembrane receptor protein tyrosine kinase activity Cellular component integral component of membrane lateral plasma membrane membrane plasma membrane integral component of plasma membrane extracellular region basolateral plasma membrane apical plasma membrane intracellular anatomical structure receptor complex extracellular space cytoplasm basal plasma membrane Biological process neuron apoptotic process negative regulation of cell adhesion phosphorylation endocardial cushion development positive regulation of protein tyrosine kinase activity wound healing MAPK cascade positive regulation of calcineurin-NFAT signaling cascade heart development protein phosphorylation negative regulation of secretion regulation of cell population proliferation extrinsic apoptotic signaling pathway in absence of ligand phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling negative regulation of signal transduction signal transduction cranial nerve development negative regulation of neuron apoptotic process Schwann cell differentiation phosphatidylinositol phosphate biosynthetic process regulation of cell motility peripheral nervous system development transmembrane receptor protein tyrosine kinase signaling pathway ERBB2 signaling pathway peptidyl-tyrosine phosphorylation positive regulation of cardiac muscle tissue development positive regulation of gene expression positive regulation of protein kinase B signaling cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade nervous system development positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2065 13867 Ensembl ENSG00000065361 ENSMUSG00000018166 UniProt P21860 Q61526 RefSeq (mRNA) NM_001982 NM_001005915 NM_010153 RefSeq (protein) NP_001005915 NP_001973 NP_034283 Location (UCSC) Chr 12: 56.08 – 56.1 Mb Chr 10: 128.4 – 128.43 Mb PubMed search [3] [4]
Wikidata
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Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound protein that in humans is encoded by the ERBB3 gene.

ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ErbB3 is known to form active heterodimers with other members of the ErbB family, most notably the ligand binding-impaired ErbB2.