ETS1

ETS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1GVJ, 2NNY, 2STT, 2STW, 3MFK, 3RI4, 3WTS, 3WTT, 3WTU, 3WTV, 3WTW, 3WTX, 3WTY, 3WTZ, 3WU0, 3WU1, 4L0Y, 4L0Z, 4L18, 4LG0
Identifiers
Aliases	ETS1, ETS-1, EWSR2, p54, c-ets-1, ETS proto-oncogene 1, transcription factor
External IDs	OMIM: 164720; MGI: 95455; HomoloGene: 3837; GeneCards: ETS1; OMA:ETS1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.3 Start 128,458,761 bp[1] End 128,587,558 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A4|9 17.97 cM Start 32,636,221 bp[2] End 32,757,820 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in visceral pleura parietal pleura tibia epithelium of nasopharynx lower lobe of lung superficial temporal artery epithelium of colon pericardium vena cava lymph node Top expressed in left lung lobe thymus mesenteric lymph nodes blood spleen Gonadal ridge right lung lobe atrium atrioventricular valve endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity transcription factor binding protein binding identical protein binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific sequence-specific double-stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific histone acetyltransferase binding Cellular component cytoplasm transcription regulator complex nucleoplasm nucleus Biological process regulation of apoptotic process pituitary gland development response to estradiol response to interleukin-1 response to hypoxia regulation of transcription, DNA-templated positive regulation of erythrocyte differentiation cell motility estrous cycle immune system process regulation of transcription by RNA polymerase II response to antibiotic female pregnancy angiogenesis involved in wound healing positive regulation of cell migration response to mechanical stimulus response to laminar fluid shear stress negative regulation of cell cycle regulation of angiogenesis transcription by RNA polymerase II regulation of extracellular matrix disassembly transcription, DNA-templated positive regulation of endothelial cell migration positive regulation of transcription, DNA-templated PML body organization response to wounding immune response positive regulation of cell population proliferation hypothalamus development negative regulation of inflammatory response positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation cellular response to hydrogen peroxide positive regulation of inflammatory response pri-miRNA transcription by RNA polymerase II positive regulation of leukocyte adhesion to vascular endothelial cell positive regulation of gene expression positive regulation of blood vessel endothelial cell migration positive regulation of angiogenesis cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2113 23871 Ensembl ENSG00000134954 ENSMUSG00000032035 UniProt P14921 P27577 RefSeq (mRNA) NM_001143820 NM_001162422 NM_005238 NM_001330451 NM_001038642 NM_011808 RefSeq (protein) NP_001137292 NP_001155894 NP_001317380 NP_005229 NP_001033731 NP_035938 NP_001359463 NP_001359464 NP_001359465 NP_001359466 Location (UCSC) Chr 11: 128.46 – 128.59 Mb Chr 9: 32.64 – 32.76 Mb PubMed search [3] [4]
Wikidata
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Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene.^[5] The protein encoded by this gene belongs to the ETS family of transcription factors.^[6]