ETS transcription factor family

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1awc, 1bc7, 1bc8, 1dux, 1fli, 1gvj, 1hbx, 1k6o, 1k78, 1k79, 1k7a, 1md0, 1mdm, 1pue, 1r36, 1wwx, 1yo5, 2nny, 2stt, 2stw

Ets-domain
Ets-domain
	Structure of Ets-1 DNA binding autoinhibition.
Identifiers
Symbol	Ets
Pfam	PF00178
Pfam clan	CL0123
InterPro	IPR000418
SMART	SM00413
PROSITE	PDOC00374
SCOP2	1r36 / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1awc, 1bc7, 1bc8, 1dux, 1fli, 1gvj, 1hbx, 1k6o, 1k78, 1k79, 1k7a, 1md0, 1mdm, 1pue, 1r36, 1wwx, 1yo5, 2nny, 2stt, 2stw

In the field of molecular biology, the ETS (E26 transformation-specific^[2] or E-twenty-six. (Erythroblast Transformation Specific)^[3]) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans^[4], 27 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding member of this family was identified as a gene transduced by the leukemia virus, E26. The members of the family have been implicated in the development of different tissues as well as cancer progression.

^ Lee GM, Donaldson LW, Pufall MA, et al. (February 2005). "The structural and dynamic basis of Ets-1 DNA binding autoinhibition". J. Biol. Chem. 280 (8): 7088–99. doi:10.1074/jbc.M410722200. PMID 15591056.
^ Nunn, M. F.; Seeburg, P. H.; Moscovici, C.; Duesberg, P. H. (1983). "Tripartite structure of the avian erythroblastosis virus E26 transforming gene". Nature. 306 (5941): 391–395. Bibcode:1983Natur.306..391N. doi:10.1038/306391a0. PMID 6316155. S2CID 4302399.
^ Leprince, D.; Gegonne, A.; Coll, J.; De Taisne, C.; Schneeberger, A.; Lagrou, C.; Stehelin, D. (1983). "A putative second cell-derived oncogene of the avian leukaemia retrovirus E26". Nature. 306 (5941): 395–397. Bibcode:1983Natur.306..395L. doi:10.1038/306395a0. PMID 6316156. S2CID 4318034.
^ Sizemore, Gina M.; Pitarresi, Jason R.; Balakrishnan, Subhasree; Ostrowski, Michael C. (June 2017). "The ETS family of oncogenic transcription factors in solid tumours". Nature Reviews Cancer. 17 (6): 337–351. doi:10.1038/nrc.2017.20. ISSN 1474-1768. PMID 28450705.

[pmid15591056-1] Lee GM, Donaldson LW, Pufall MA, et al. (February 2005). "The structural and dynamic basis of Ets-1 DNA binding autoinhibition". J. Biol. Chem. 280 (8): 7088–99. doi:10.1074/jbc.M410722200. PMID 15591056.

[2] Nunn, M. F.; Seeburg, P. H.; Moscovici, C.; Duesberg, P. H. (1983). "Tripartite structure of the avian erythroblastosis virus E26 transforming gene". Nature. 306 (5941): 391–395. Bibcode:1983Natur.306..391N. doi:10.1038/306391a0. PMID 6316155. S2CID 4302399.

[3] Leprince, D.; Gegonne, A.; Coll, J.; De Taisne, C.; Schneeberger, A.; Lagrou, C.; Stehelin, D. (1983). "A putative second cell-derived oncogene of the avian leukaemia retrovirus E26". Nature. 306 (5941): 395–397. Bibcode:1983Natur.306..395L. doi:10.1038/306395a0. PMID 6316156. S2CID 4318034.

[4] Sizemore, Gina M.; Pitarresi, Jason R.; Balakrishnan, Subhasree; Ostrowski, Michael C. (June 2017). "The ETS family of oncogenic transcription factors in solid tumours". Nature Reviews Cancer. 17 (6): 337–351. doi:10.1038/nrc.2017.20. ISSN 1474-1768. PMID 28450705.

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