EXTL2

EXTL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OMX, 1OMZ, 1ON6, 1ON8
Identifiers
Aliases	EXTL2, EXTR2, exostosin-like glycosyltransferase 2, exostosin like glycosyltransferase 2
External IDs	OMIM: 602411; MGI: 1889574; HomoloGene: 1102; GeneCards: EXTL2; OMA:EXTL2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.2 Start 100,872,372 bp[1] End 100,895,179 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 115,801,111 bp[2] End 115,822,666 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in periodontal fiber postcentral gyrus Brodmann area 46 lateral nuclear group of thalamus ventricular zone right adrenal cortex superior frontal gyrus left adrenal gland left adrenal cortex stromal cell of endometrium Top expressed in facial motor nucleus motor neuron substantia nigra anterior horn of spinal cord lobe of cerebellum cerebellar vermis pineal gland habenula deep cerebellar nuclei medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity metal ion binding glycosyltransferase activity glycosaminoglycan binding manganese ion binding alpha-1,4-N-acetylgalactosaminyltransferase activity glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity Cellular component integral component of membrane extracellular region endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process heparan sulfate proteoglycan biosynthetic process N-acetylglucosamine metabolic process UDP-N-acetylgalactosamine metabolic process IRE1-mediated unfolded protein response protein glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2135 58193 Ensembl ENSG00000162694 ENSMUSG00000027963 UniProt Q9UBQ6 Q9ES89 RefSeq (mRNA) NM_001033025 NM_001261440 NM_001261441 NM_001261442 NM_001439 NM_001163514 NM_001163515 NM_021388 RefSeq (protein) NP_001028197 NP_001248369 NP_001248370 NP_001248371 NP_001430 NP_001156986 NP_001156987 NP_067363 Location (UCSC) Chr 1: 100.87 – 100.9 Mb Chr 3: 115.8 – 115.82 Mb PubMed search [3] [4]
Wikidata
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Exostosin-like 2 is a protein that in humans is encoded by the EXTL2 gene.^[5][6][7] EXTL2 Glycosyltransferase is required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. (https://www.phosphosite.org/overviewExecuteAction?id=5020882)