EZH1

EZH1
Identifiers
Aliases	EZH1, KMT6B, enhancer of zeste 1 polycomb repressive complex 2 subunit
External IDs	OMIM: 601674; MGI: 1097695; HomoloGene: 20458; GeneCards: EZH1; OMA:EZH1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	42,745,049 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	101,117,289 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; tibial nerve; ; dorsal motor nucleus of vagus nerve; ; Achilles tendon; ; left ovary; ; sural nerve; ; olfactory bulb; ; right ovary; ; canal of the cervix;
	Top expressed in
	ciliary body; ; iris; ; motor neuron; ; retinal pigment epithelium; ; ankle; ; zygote; ; vestibular membrane of cochlear duct; ; dentate gyrus of hippocampal formation granule cell; ; granulocyte; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; chromatin binding; histone-lysine N-methyltransferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA binding; transcription corepressor activity;
Cellular component	ESC/E(Z) complex; nucleus; nucleoplasm; telomere;
Biological process	histone H3-K27 methylation; anatomical structure morphogenesis; methylation; regulation of transcription, DNA-templated; hippocampus development; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; chromatin organization; negative regulation of transcription by RNA polymerase II; chromatin remodeling;
	Sources:Amigo / QuickGO
Orthologs
	2145
	14055
	ENSG00000108799
	ENSMUSG00000006920
	Q92800
	P70351
	NM_001991; NM_001321079; NM_001321081; NM_001321082
	NM_007970
	NP_001308008; NP_001308010; NP_001308011; NP_001982
NP_031996; NP_001390736; NP_001390738; NP_001390739; NP_001390740;
	NP_001390741; NP_001390742; NP_001390743; NP_001390744; NP_001390745; NP_001390747; NP_001390750; NP_001390751
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-lysine N-methyltransferase EZH1 is an enzyme that in humans is encoded by the EZH1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108799 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006920 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL (Feb 1997). "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics. 37 (2): 161–71. doi:10.1006/geno.1996.0537. PMID 8921387.
^ "Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108799 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006920 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8921387-5] Abel KJ, Brody LC, Valdes JM, Erdos MR, McKinley DR, Castilla LH, Merajver SD, Couch FJ, Friedman LS, Ostermeyer EA, Lynch ED, King MC, Welcsh PL, Osborne-Lawrence S, Spillman M, Bowcock AM, Collins FS, Weber BL (Feb 1997). "Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1". Genomics. 37 (2): 161–71. doi:10.1006/geno.1996.0537. PMID 8921387.

[entrez-6] "Entrez Gene: EZH1 enhancer of zeste homolog 1 (Drosophila)".

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